2013 Fiscal Year Final Research Report
Control of multiwall carbon nanotube-induced inflammatory responses by cellular cholesterol
| Project/Area Number |
23590164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUHIRA Keiichiro 国立医薬品食品衛生研究所, 機能生化学部, 室長 (10425671)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ナノ材料 / カーボンナノチューブ / コレステロール / インフラマソーム / IL-1β / NLRP3 |
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| Research Abstract |
Because cnanotubes have asbestos-like shape and size, concerns about their adverse effect on environment and health have been raised. Studies have shown their association with inflammation, mesothelioma, and atherosclerosis progression in mice. In this study, we investigated the mechanism by which multiwall carbon nanotubes (MWCNT)-induced production of an inflammatory cytokine IL-1beta is regulated by cholesterol. We found that MWCNTs were incorporated into THP-1 macrophages and induced IL-1beta maturation via NLRP3 inflammasome activation. This effect is enhanced by dispersion of MWCNTs with lung-surfactant-like phospholipids. Various statins repressed MWCNT-induced IL-1beta release by reducing cellular uptake of MWCNTs.
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[Presentation] High-temperature calcined fullerene nanowhiskers and multi-wall carbon nanotubes have abilities to induce IL-1beta secretion through NLRP3-dependent mechanism depending on their lengths2013
Author(s)
Nishimaki-Mogami T, Cui H, Wu W, Okuhira K, Naito M, Nishimura T, Sakamoto Y, Ogata A, Maeno T, Inomata A, Nakae D, Miyazawa K, Hirose A
Organizer
Eurotox2013
Place of Presentation
Interlaken, Switzerland
Year and Date
2013-09-03
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