2013 Fiscal Year Final Research Report
The pharmaco-epidemiological study about serious and opportunistic infections under treatment of the biologics and the molecular target medicine.
| Project/Area Number |
23590171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TANAKA Michi 東京医科歯科大学, 医学部, 非常勤講師 (50277141)
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| Co-Investigator(Kenkyū-buntansha) |
NANNKI Toshihiro 帝京大学, 医学部, 准教授 (00282749)
KOIKE Ryuji 東京医科歯科大学, 医学部附属病院, 准教授 (50250220)
HARIGAI Masayoshi 東京医科歯科大学, 医学部, 教授 (20238207)
MIYASAKA Nobuyuki 東京医科歯科大学, 医学部, 非常勤講師 (30157622)
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| Project Period (FY) |
2011 – 2013
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| Keywords | リウマチ性疾患 / 関節リウマチ / 免疫抑制療法 / 生物学的製剤 / 肺感染症 / 日和見感染症 |
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| Research Abstract |
Prospective cohort study to identify risk factors for development of pulmonary infection in patients receiving immunosuppressive treatment for rheumatic diseases.: 766 patients with rheumatic disease enrolled. Older age, higher Brinkman index, higher serum Cr level, and disturbed performance status were significantly associated with development of pulmonary infection.
Pneumocystis jirovecii pneumonia (PCP) in patients with rheumatoid arthritis receiving adalimumab: a retrospective review and case-control study of 17 patients.: Data from 17 RA patients who were diagnosed with PCP and from 89 RA patients who did not develop PCP during adalimumab treatment were collected. The patients with PCP were significantly older and had more structural changes than the patients without PCP.
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[Journal Article] Clinical characteristics and risk factors for Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis receiving adalimumab : a retrospective review and case-control study of 17 patients2013
Author(s)
Watanabe K, Sakai R, Koike R, Sakai F, Sugiyama H, Tanaka M, Komano Y, Akiyama Y, Mimura T, Kaneko M, Tokuda H, Iso T, Motegi M, Ikeda K, Nakajima H, Taki H, Kubota T, Kodama H, Sugii S, Kuroiwa T, Nawata Y, Shiozawa K, Ogata A, Sawada S, Matsukawa Y, Okazaki T, Mukai M, Iwahashi M, Saito K, Tanaka Y, Nanki T, Miyasaka N, Harigai M
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Journal Title
Mod Rheumatol
Volume: 23(6)
Pages: 1085-93
Peer Reviewed
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