Anti-tumor effect of macrolide antibiotics on MALT lymphoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 23590188
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Nagasaki University
• Principal Investigator: ISHIMATSU Yuji 長崎大学, 医歯薬学総合研究科(保健学科), 教授 (40533899)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: MALTリンパ腫 / マクロライド系抗菌薬 / アポトーシス

Outline of Final Research Achievements

This study was aimed at determining whether macrolide antibiotics (MCL) have a direct anti-tumor effect on mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric and pulmonary MALT lymphomas were immunohistochemically examined for Bcl-xL (apoptosis regulator) expression. Patients with a good clinical course after MCL administration showed high Bcl-xL expression, whereas those with a poor response to MCL showed no or very faint Bcl-xL expression. The results of this study suggest that the direct anti-tumor effect of MCL on MALT lymphoma could be predicted by Bcl-xL expression.

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