2013 Fiscal Year Final Research Report
Studies on disposition of tacrolimus after topical application using several experimental models including a new hybrid skin-model
| Project/Area Number |
23590197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Josai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
EGAWA Yuya 城西大学, 薬学部, 准教授 (90400267)
OSHIMA Shinji 城西大学, 薬学部, 助手 (00438798)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 薬物動態 / 代謝学 / 経皮吸収 |
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| Research Abstract |
In this study, I examined factors affecting disposition of tacrolimus after topical application using several experimental models including a new hybrid skin-model. Systemic absorption of tacrolimus depended on the barrier function of stratum corneum was shown in hairless rat model and the new hybrid skin-model. Trans Epidermal Water Loss (TEWL) was correlated with the systemic absorption of tacrolimus and it was suggested that preliminary determination of TEWL is useful to avoid the systemic side effect. In inflamed skin, although delayed absorption was caused by tacrolimus binding to leaching plasma proteins in the dermis, increased blood flow and blood vessel permeability in the inflamed skin can be related with high blood concentration of tacrolimus in the later phase. The results obtained in this study can be applicable for safe medication of atopic dermatitis using tacrolimus ointment.
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