2013 Fiscal Year Final Research Report
Quantitative prediction of drug interactions based on the inhibition of hepatic uptake transporters
| Project/Area Number |
23590204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Musashino University |
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Principal Investigator |
ITO Kiyomi 武蔵野大学, 薬学研究所, 教授 (60232435)
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| Co-Investigator(Kenkyū-buntansha) |
KUDO Toshiyuki 武蔵野大学, 薬学研究所, 助教 (10584815)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 薬物間相互作用 / 生理学的薬物速度論 / 定量的予測 / トランスポーター |
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| Research Abstract |
Drug-drug interactions involving the hepatic uptake transporters were analyzed based on a physiologically based pharmacokinetic model. As an example, the repaglinide concentration increase by co-administration of itraconazole and gemfibrozil was quantitatively explained by the inhibition of both hepatic uptake and metabolism of repaglinide. Application of the present model analysis to quantitative predictions of drug interactions involving hepatic uptake transporters is expected to facilitate the increased efficiency in drug development and avoidance of toxic interactions.
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