2013 Fiscal Year Final Research Report
Development of the effective ophthalmic formulations that simultaneously targeting intraocular pressure and optic nerve
| Project/Area Number |
23590208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Noriaki 近畿大学, 薬学部, 講師 (90411579)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ピログルタミン酸 / 緑内障 / シクロデキストリン / 眼圧 / 視神経 / 一酸化窒素 / 眼瞼適用ゲルパッチ / 網膜 |
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| Research Abstract |
We demonstrated that the treatment of L-pyroglutamic acid decreased the enhanced intraocular pressure, and enhanced the survival of retinal ganglion cells after optic nerve transection in the in vivo study. In addition, we tried to develop the transdermal drug delivery system for ophthalmic therapy. It is possible that the transdermal ophthalmic therapy by using L-pyroglutamic acid provide the effective therapy for glaucoma patient.
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Research Products
(3 results)
