Structure and function of the vitamin A-storing cells in the digestive tract

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590228
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Akita University
• Principal Investigator: SENOO Haruki 秋田大学, 医学(系)研究科(研究院), 教授 (90171355)
• Co-Investigator(Kenkyū-buntansha): MEZAKI Yoshihiro 秋田大学, 大学院医学系研究科, 助教 (40431621) ; YOSHIKAWA Kiwamu 秋田大学, 大学院医学系研究科, 助教 (90400481)
• Project Period (FY): 2011 – 2013
• Keywords: 消化管 / 粘膜固有層 / ビタミンA / ビタミンA貯蔵細胞

Research Abstract

Vitamin A (retinyl palmitate) was injected subcutaneously or administered to rats by tube feeding. After subcutaneous injection, vitamin A was taken up and stored in cells in lamina propria mucosae of the rat intestine. After oral administration, vitamin A was absorbed from intestinal absorptive epithelial cells and transferred to the lamina propria mucosae; cells in the lamina propria mucosae took and stored the transferred vitamin A. Morphology of these cells was similar to that of a hepatic stellate cells (also called vitamin A-storing cell, lipocyte, interstitial cell, fat-storing cell, or Ito cell). Thus, these cells in the intestine can take up vitamin A from both of the systemic circulation and intestinal absorption, and store the vitamin in the lipid droplets in the cytoplasm. These data suggest that these cells are extrahepatic stellate cells of the digestive tract and may play roles in absorption and homeostasis of vitamin A.

Research Products

• [Journal Article] Uptake and storage of vitamin A as lipid droplets in the cytoplasm of cells in the lamina propria mucosae of the rat intestine (2013)
  • Author(s): Senoo H, Mezaki,Y, Morii M, Hebiguchi T, Miura M, Imai K
  • Journal Title: Cell Biol Int Volume: 37 Pages: 1171-1180
  • Peer Reviewed
• [Journal Article] 肝臓星細胞によるビタミンAの代謝・貯蔵メカニズムとその意義ビタミン特集「ビタミン基礎研究の進展を担う若手研究者たち」 (2013)
  • Author(s): 目崎喜弘
  • Journal Title: 第54回大会若手シンポジウム Volume: ミニレビュー87 Pages: 33-37
  • Peer Reviewed
• [Journal Article] 視覚・ビタミンA貯蔵の進化とレシチン:レチノールアシルトランスフェラーゼEvolutions of vision and vitamin A storage with special reference to lecithin : retinhol acyltransferase (2013)
  • Author(s): 目崎喜弘
  • Journal Title: ビタミン Volume: 87 Pages: 282-283
  • Peer Reviewed
• [Journal Article] 細胞質に局在するレチノイン酸受容体とそのはたらきCytosolic localization of retinoic acid receptor and its function (2013)
  • Author(s): 目崎喜弘
  • Journal Title: ビタミン Volume: 87 Pages: 579-580
  • Peer Reviewed
• [Journal Article] ビタミンA貯蔵細胞系(星細胞系)と生物多様性 (2012)
  • Author(s): 妹尾春樹, 目崎喜弘, 三浦光隆, 森井真也子, 今井克幸, 藤原睦憲
  • Journal Title: ビタミン Volume: 86 Pages: 381-389
  • Peer Reviewed
• [Journal Article] ヤツメウナギ細胞質レチノール結合タンパク質のキャラクタリゼーション (2012)
  • Author(s): 目崎喜弘, 森井真也子, 吉川究, 山口典子, 三浦光隆, 今井克幸, 吉野裕顕, 妹尾春樹
  • Journal Title: ビタミン Volume: 86 Pages: 313-315
  • Peer Reviewed
• [Journal Article] Characterization of a cellular retinol binding protein from lamprey, Lethenteron japonicum. CBP Part B (2012)
  • Author(s): Mezaki, M., Morii, M., Yoshikawa, K., Yamaguchi, N., Miura, M. , Imai, K., Yoshino, H., Senoo, H
  • Journal Title: Biochemistry & Molecular Biology Volume: 161 Pages: 233-239
  • Peer Reviewed
• [Journal Article] 小児における腸管不全合併肝障害に対するω3系脂肪製剤投与の検討 (2012)
  • Author(s): 森井真也子、吉野裕顕、蛇口琢、渡部亮、目崎喜弘、南條博、妹尾春樹、和田基、仁尾正記、蛇口達造
  • Journal Title: 外科と代謝 Volume: 46 Pages: 159-167
  • Peer Reviewed
• [Presentation] 腸の結合組織(粘膜固有層)に局在するビタミンA貯蔵細胞の形態と機能 (2013)
  • Author(s): 妹尾春樹、目崎喜弘、森井真也子、蛇口琢、吉野裕顕、三浦光隆、今井克幸
  • Organizer: 第45回日本結合組織学会学術大会、第60回日本マトリックス研究会大会合同学術大会
  • Place of Presentation: 和歌山
  • Year and Date: 20130600
• [Presentation] Uptake and storage of vitamin A by cells in lamina propria mucosae of rat intestine (2013)
  • Author(s): Senoo H, Mazaki Y, Morii M, Hebiguchi T, Miura M, Yoshino H, Imai K
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 香川
  • Year and Date: 20130300
• [Presentation] ラット小腸粘膜固有層の細胞におけるレチノイドの取り込みと貯蔵 (2012)
  • Author(s): 妹尾春樹、目崎喜弘、森井真也子、蛇口琢、三浦光隆、吉野裕顕、今井克幸
  • Organizer: 第23回レチノイド研究会学術集会
  • Place of Presentation: 米子
  • Year and Date: 20121000
• [Presentation] 細胞内レチノール結合タンパク質の分子進化とビタミンA貯蔵 (2012)
  • Author(s): 目崎喜弘、蛇口琢、森井真也子、吉川究、山口典子、三浦光隆、今井克幸、吉野裕顕、妹尾春樹
  • Organizer: 第3回分子生命研究会(旧秋田県電気泳動研究会)
  • Place of Presentation: 秋田
  • Year and Date: 20120900
• [Presentation] ビタミンA貯蔵細胞と生物多様性 (2012)
  • Author(s): 妹尾春樹、目崎喜弘,三浦光隆,森井真也子,今井克幸,藤原睦憲
  • Organizer: 第336回脂溶性ビタミン総合研究委員会
  • Place of Presentation: 東京
  • Year and Date: 20120900
• [Presentation] 肝臓星細胞によるビタミンAの代謝・貯蔵メカニズムとその意義 (2012)
  • Author(s): 目崎喜弘
  • Organizer: 日本ビタミン学会第64回大会、岐阜若手シンポジウム「ビタミン基礎研究の進展を担う若手研究者たち」
  • Year and Date: 20120600
• [Presentation] 肝臓星細胞と生物多様性 (2012)
  • Author(s): 妹尾春樹、目崎喜弘,三浦光隆,森井真也子,今井克幸,藤原睦憲
  • Organizer: 第19回肝細胞研究会
  • Place of Presentation: 札幌
  • Year and Date: 20120600
• [Presentation] 分子レベルで考察するヤツメウナギのビタミンA貯蔵 (2012)
  • Author(s): 目崎喜弘、森井真也子、吉川究、山口典子、三浦光隆、今井克幸、吉野裕顕、妹尾春樹
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨
  • Year and Date: 20120300
• [Presentation] The metabolism of cholesterol after bile duct degeneration in lamprey (2012)
  • Author(s): Morii, M., Mezaki, Y., Yamaguchi, N., Yoshikawa, K., Miura, M., Imai, K., Hebiguchi, T., Watanabe, R., Yoshino, H., Senoo, H
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨
  • Year and Date: 20120300
• [Book] The stellate cell (vitamin A-storing cell) system (2014)
  • Author(s): Senoo H
  • Total Pages: 1-245
  • Publisher: Nova Science Publishers, New York, ISBN : 978-1-62808-516-7