2015 Fiscal Year Final Research Report
Transcriptional mechanism for maintenance and differentiation of neural stem cells
| Project/Area Number |
23590237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
USUI Noriyoshi
BEPARI Asim
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Keywords | オリゴデンドロサイト / 分化 / ミエリン |
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| Outline of Final Research Achievements |
Oligodenrocytes are glial cells in the central nervous system which are produced from neural stem cells during neural development. Olig2 is an essential transcription factor for oligodendrocyte development.In this study, we screened Olig2-binding proteins. We identified Olig2 binding proteins (OBP1 and OBP2). Overexpression experiment of OBP2 in embryonic mouse brain resulted in elevated expression of myelin-related genes. In addition, generation of central nervous system (CNS)-specific conditional knockout mice resulted in postnatal lethality with CNS abnormality.
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| Free Research Field |
神経解剖学
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