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2013 Fiscal Year Final Research Report

The chronological observation of molecular expression and morphological changes in a unique pituitary cell death processes.

Research Project

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Project/Area Number 23590240
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionOsaka City University

Principal Investigator

OGAWA Tokiko  大阪市立大学, 医学(系)研究科(研究院), 博士研究員 (30382229)

Project Period (FY) 2011 – 2013
Keywords持続的ストレス / 下垂体 / 微細形態 / 細胞死
Research Abstract

Continuous stress induces unique cell death in a population of pituitary cell, melanotroph of a rat model. Melanotroph was first hyper-activated in hormone synthesis and secretion under continuous stress, and after that fell into catastrophic cell death finally. We analyzed the process of melanotroph cell death chronologically, focused on the changes in organelle morphology and molecular expression. Resulted appeared followings, 1) there were at least three types of melanotroph cell death, 2) some disorders of intracellular protein or organelle recycling system were observed during the process toward to those cell death, 3) the common morphological feature of dying melanotrophs was ruptured plasma membrane.

  • Research Products

    (10 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Dysfunction in the hypothalamo- hypophyseal system under chronic stress and fatigue2013

    • Author(s)
      Ogawa T., Konishi H., Kiyama H
    • Journal Title

      Advance in Neuroimmune Biology

      Volume: 4 Pages: 219-228

    • DOI

      10.3233/NIB-130070

    • Peer Reviewed
  • [Journal Article] Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine2013

    • Author(s)
      Tokizane K., Konishi H., Yasui M., Ogawa T., Sasaki K., Minamino N., Kiyama H
    • Journal Title

      Mol Cell Endocrinol

      Volume: 372 (1-2): Pages: 49-56

    • DOI

      10.1016/j.mce.2013.03.012

    • Peer Reviewed
  • [Journal Article] The absence of somatotroph proliferation during continuous stress is a result of the lack of Extracellular signal-regulated kinase 1/2 activation2012

    • Author(s)
      Ogawa T., Sei H., Konishi H. Shishioh-Ikejima N., Kiyama H
    • Journal Title

      J Neuroendocrinol

      Volume: 24 Pages: 1335-1345

    • DOI

      10.1111/j.1365-2826.2012.02338.x

    • Peer Reviewed
  • [Presentation] 持続的ストレス負荷ラットに起こる下垂体メラノトロフ細胞死の多様性2014

    • Author(s)
      小川登紀子、渡辺恭良、木山博資
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木
    • Year and Date
      2014-03-29
  • [Presentation] 疲労モデルラット縫線核におけるセロトニン合成酵素の発現変化2013

    • Author(s)
      小川登紀子, 他
    • Organizer
      第9回日本疲労学会総会・学術集会
    • Year and Date
      20130600
  • [Presentation] 慢性的小胞体ストレスによる下垂体メラノトロフの運命とCHOP (C/EBP homologus protein)発現2013

    • Author(s)
      小川登紀子, 他
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Year and Date
      2013-03-28
  • [Presentation] 持続的ストレス負荷による下垂体細胞の形態変化と機能変調2012

    • Author(s)
      小川登紀子、木山博資
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-26
  • [Presentation] 持続的ストレスラットにおける下垂体ホメオスタシスの破綻2011

    • Author(s)
      小川登紀子
    • Organizer
      第64回日本自律神経学会総会
    • Place of Presentation
      秋田
    • Year and Date
      2011-10-28
  • [Presentation] ラット過労モデルの自発行動に対する抑肝散の効果2011

    • Author(s)
      小川登紀子, 他
    • Organizer
      第7回日本疲労学会総会・学術集会
    • Place of Presentation
      愛知
    • Year and Date
      2011-05-22
  • [Remarks]

    • URL

      http://www.med.osaka-cu.ac.jp/physiol/index.htm

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Published: 2015-07-16  

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