2013 Fiscal Year Final Research Report
Clarification of novel regulatory mechanism of intercellular junction in renal tubules
| Project/Area Number |
23590263
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Gifu Pharmaceutical University (2013)
University of Shizuoka (2011-2012) |
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Principal Investigator |
IKARI Akira 岐阜薬科大学, 薬学部, 教授 (50315850)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腎臓 / タイト結合 / クローディン / リン酸化 / 会合 / 転写調節 |
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| Research Abstract |
Tight junctions, which seal adjacent epithelial cells in a narrow band, composes a large complex of proteins including transmembrane, scaffolding, and transcriptional proteins. Claudins are tetraspanning proteins and comprise a superfamily of more than 20 homologus isoforms. Different combinations of claudins can confer different properties to epithelial cells. However, the regulatory mechanisms of claudins expression remain largely unknown. We investigated the regulatory mechanisms of claudins expression in the renal tubule and found the novel transcriptional mechanism of claudin-2 and -4, and intracellular trafficking mechanism of claudin-16. Furthermore, we clarified the novel function of claudin-2 and -4 against hyperosmotic stress.
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Research Products
(27 results)
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[Journal Article] Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells2014
Author(s)
Akira Ikari, Chie Tonegawa, Ayumi Sanada, Toru Kimura, Hideki Sakai, Hisayoshi Hayashi, Hajime Hasegawa, Masahiko Yamaguchi, Yasuhiro Yamazaki, Satoshi Endo, Toshiyuki Matsunaga, Junko Sugatani
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Journal Title
J. Biol. Chem.
Volume: 289
Pages: 13112-13123
DOI
Peer Reviewed
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