2014 Fiscal Year Final Research Report
Regulatory mechanism for ion transporters in renal tubules
| Project/Area Number |
23590265
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Takaaki 東北大学, 大学院医工学研究科, 教授 (80292209)
KAWAHARA Katsumasa 北里大学, 医学部, 教授 (70134525)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | カリウムチャネル / 尿細管輸送 / 細胞内局在 / Gitelman症候群 / EAST症候群 / 電解質恒常性 / ナトリウム輸送 |
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| Outline of Final Research Achievements |
The distal convoluted tubule (DCT) of the kidney is the regulatory segment for the electrolyte homeostasis. At the DCT, basolaterally expressed Na+/K+ ATPase provides the driving force for electrolyte transport and the process of K+ excretion, known as K+ recycling, is the rate-limiting step in the electrolyte transport at the DCT. The functional defect in the K+ pathway reduces the K+ recycling and causes salt waste from the kidney. In this study, we found that intracellular mistrafficking of the K+ pathway of the basolateral side contributes to the pathogenesis of renal salt waste.
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| Free Research Field |
腎臓病学
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