Effects of monoamine on the prefrontal cortical neurons and amygdaloid nuclei neurons

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590269
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Kurume University
• Principal Investigator: TANAKA Eiichiro 久留米大学, 医学部, 教授 (80188284)
• Co-Investigator(Kenkyū-buntansha): MURAI Yoshinaka 久留米大学, 医学部, 准教授 (40322820)
• Project Period (FY): 2011 – 2013
• Keywords: 受容体 / 細胞内シグナル伝達 / シナプス伝達

Research Abstract

Superfusion of dopamine (10 micro M) induced depolarization with reduction in input resistance in 15% of pyramidal neurons and in 27% of multipolar neurons of the II - III layer of prefrontal cortex in rats, which was mediated by dopamine D2 like receptors. Low concentration (0.1 micro M) of dopamine increased and high concentration (100 micro M) of dopamine decreased the amplitude of fast excitatory and fast inhibitory synaptic potentials (EPSPs and IPSPs). A D2 like receptor agonist reduced the amplitude of fast inhibitory synaptic currents more effectively than the amplitude of fast excitatory synaptic currents, indicating that disinhibition might induce the increase in fast EPSPs. Electrical tetanus stimuli induced long-term inhibition of field EPSPs and the simultaneous application of dopamine (100 micro M) and tetanus stimuli induced long-term potentiation of field EPSPs, therefore, presence of dopamine might contribute to the cognition and memory in the prefrontal cortex.

Research Products

• [Journal Article] The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease (Review) (2013)
  • Author(s): Kikuchi, K., Tancharoen, S., Takeshige, N., Yoshitomi, M., Morioka, M., Murai, Y., Tanaka, E.
  • Journal Title: Int. J. Mol. Sci Volume: 14 Pages: 13909-13930
  • Peer Reviewed
• [Journal Article] Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke (Review) (2013)
  • Author(s): Kikuchi, K., Miura, N., Kawahara, K., Murai, Y., Morioka, M., Lapchak, P., Tanaka, E.
  • Journal Title: Biomedical Reports Volume: 1 Pages: 7-12
  • Peer Reviewed
• [Journal Article] Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke (2012)
  • Author(s): Kikuchi, K., Uchikado, H., Morioka, M., Murai, Y., Tanaka, E.
  • Journal Title: Int. J. Mol. Sci Volume: 13 Pages: 7739-7761
  • Peer Reviewed
• [Journal Article] Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome (2012)
  • Author(s): Okabe, Y., Takahashi, T., Mitsumasu, C., Kosai, K., Tanaka, E., Matsuishi, T.
  • Journal Title: PLoS ONE Volume: 7(4) Pages: e35354
  • DOI: 10.1371/journal.pone.0035354
  • Peer Reviewed
• [Journal Article] Activation of protein kinase A and C prevents recovery from persistent depolarization produced by oxygen and glucose deprivation in rat hippocampal neurons (2012)
  • Author(s): Murai, Y., Okabe, Y., Tanaka, E.
  • Journal Title: J. Neurophysiol Volume: 107 Pages: 2517-2525
  • Peer Reviewed
• [Presentation] The alteration of glutamate clearance in astrocytes derived from MeCP2-null mouse (2013)
  • Author(s): Okabe Y, Takahasi T, Mitsumasu C, Murai Y, Matsuishi T, Tanaka E
  • Organizer: The Proceedings of the 90th Annual Meeting of The Physiological Society of Japan
  • Place of Presentation: Tokyo(Abstract (Suppl.) S261)
  • Year and Date: 20130000
• [Presentation] Electrophysiological analysis of RTT model ES cell-derived neurons (2011)
  • Author(s): Okabe Y, Kusaga A, Takahashi T, Mitsumasu C, Murai Y, Higashi H, Matsuishi T, Kosai K, Tanaka E
  • Organizer: The Proceedings of the 88th Annual Meeting of The Physiological Society of Japan
  • Place of Presentation: Yokohama(Abstract (Suppl.) S172)
  • Year and Date: 20110000
• [Presentation] Activation of protein kinase A contributes to the persistent depolarization induced by in vitro ischemia (2011)
  • Author(s): Murai Y, Tanaka E
  • Organizer: The Proceedings of the 88th Annual Meeting of The Physiological Society of Japan
  • Place of Presentation: Yokohama(Abstract (Suppl.) S168)
  • Year and Date: 20110000