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2013 Fiscal Year Final Research Report

Role of orexin system in coordinating ultradian rhythm

Research Project

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Project/Area Number 23590280
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKagoshima University

Principal Investigator

OOTSUKA Youichirou  鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (70302403)

Co-Investigator(Renkei-kenkyūsha) YAMANAKA Akihiro  名古屋大学, 環境医学研究科, 教授 (60323292)
KUWAKI Tomoyuki  鹿児島大学, 大学院医歯学総合研究科, 教授 (80205260)
Project Period (FY) 2011 – 2013
Keywordsオレキシン / 生体リズム / 遺伝子改変マウス
Research Abstract

The aim of the present project is to explore brain system that coordinates the ultradian rhythm, focusing orexin, a neuropeptide that is important to promote wakefulness. The project investigated ultradian pattern in genetically-modified mice that have a deficient of orexin or of orexin neurons. In the wild type, body temperature and heat rate increased episodically at every approximately 90 min, confirming the existence of the ultradian rhythm in mice as with rats. In orexin-related transgenic mice, the amplitude of ultradian increase in body temperature and locomotor activity was significantly reduced. The project also employed optogenetically-modified mice in which orexin neuronal activity can be controlled by focal light illumination. Long lasting activation of orexin neurons attenuated the amplitude of the ultradian rhythm. These data suggest that orexin system is important for coordinating ultradian rhythm in body temperature and locomotor activity.

  • Research Products

    (27 results)

All 2014 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (21 results) (of which Invited: 2 results)

  • [Journal Article] Brown adipose tissue thermogenesis contributes to emotional hyperthermia in a resident rat suddenly confronted with an intruder rat2014

    • Author(s)
      Mohammed M, Ootsuka Y, Blessing W
    • Journal Title

      Am J Physiol

      Volume: 305 Pages: R394-400

    • DOI

      10.1152/ajpregu.00475.2013

    • Peer Reviewed
  • [Journal Article] Brown adipose tissue thermogenesis, the basic rest- activity cycle, meal initiation, and bodily homeostasis in rats2013

    • Author(s)
      Blessing W, Mohammed M, Ootsuka Y
    • Journal Title

      Physiol Behav

      Volume: 121 Pages: 61-60

    • DOI

      10.1016/j.physbeh.2013.03.028

    • Peer Reviewed
  • [Journal Article] 交感神経活動の中枢神経回路2013

    • Author(s)
      大塚曜一郎, 桑木共之
    • Journal Title

      Cardiovascular Frontier

      Volume: 第17号 Pages: 15-20

  • [Journal Article] Inactivation of neuronal function in the amygdaloid region reduces tail artery blood flow alerting responses in conscious rats2013

    • Author(s)
      Mohammed M, Kulasekara K, De Menezes RC, Ootsuka Y, Blessing WW
    • Journal Title

      Neuroscience

      Volume: 228 Pages: 13-22

    • DOI

      10.1016/j.neuroscience.2012.10.008

    • Peer Reviewed
  • [Journal Article] Brown adipose tissue thermogenesis precedes food intake in genetically obese Zucker (fa/fa) rats2013

    • Author(s)
      Kontos A, de Menezes RC, Ootsuka Y, Blessing W
    • Journal Title

      Physiol Behav

      Volume: 118 Pages: 129-137

    • DOI

      10.1016/j.physbeh.2013.05.021

    • Peer Reviewed
  • [Journal Article] Heating and eating : brown adipose tissue thermogenesis precedes food ingestion as part of the ultradian basic rest-activity cycle in rats2012

    • Author(s)
      Blessing W, Mohammed M, Ootsuka Y
    • Journal Title

      Physiol Behav

      Volume: 105 Pages: 966-974

    • DOI

      10.1016/j.physbeh.2011.11.009

    • Peer Reviewed
  • [Presentation] Orexin contributes to feeding and drinking behaviour indeced by methamphetamine2014

    • Author(s)
      生駒葉子, 桑木共之, 大塚曜一郎
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-03-17
  • [Presentation] THE CONTRIBUTION OF OREXIN SYSTEM TO INTEGRATED ULTRADIAN PHYSIOLOGICAL PATTERN2014

    • Author(s)
      Ootsuka Y, Miyata K, Ikoma Y, Kuwaki T, Yamanaka A
    • Organizer
      The 34th Annual Meeting of the Australasian Neuroscience Societ
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2014-01-30
  • [Presentation] NVOLVEMENT OF OREXIN IN METHAMPHETAMINE- INDUCED HYPOPHAGIA AND HYPERACTIVITY2014

    • Author(s)
      Ikoma Y, Kuwaki T, Ootsuka Y
    • Organizer
      The 34th Annual Meeting of the Australasian Neuroscience Society
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2014-01-29
  • [Presentation] The Basic Rest- Activity Cycle (BRAC) is present in transgenic rats with ataxin3- mediated destruction of orexin neurones, but amplitude of the BRAC- associated brown adipose tissue and body temperature change are reduced2013

    • Author(s)
      Blessing WW, Mohammed M, Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      UK
    • Year and Date
      20130721-26
  • [Presentation] A role of glutamate co- released from orexin neurons in methamphetamine- induced autonomic physiological response2013

    • Author(s)
      Ikoma Y, Kuwaki T, Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      20130721-26
  • [Presentation] Transgenic Sprague Dawley rats with ataxin3- mediated destruction of orexin neurons display reduced tail artery Sympathetic Cutaneous Vasomotor Alerting Responses (SCVARs)2013

    • Author(s)
      Mohammed M, Ootsuka Y, Yanagisawa M, Blessing WW
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      20130721-26
  • [Presentation] udden access to live cochroaches increases brown adipose tissue (BAT) thermogenesis in conscious unrestrained rats2013

    • Author(s)
      Blessing WW, Mohammed, M, Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      20130721-26
  • [Presentation] オレキシンニューロンに共存するグルタミン酸はストレス誘発性熱産生に重要である2013

    • Author(s)
      宮田紘平, 大塚曜一郎, 桑木共之
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
  • [Presentation] メタアンフェタミンー生理反応でのオレキシン共存伝達物質であるグルタミン酸の役割2013

    • Author(s)
      生駒葉子, 宮田紘平, 桑木共之, 大塚曜一郎
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
  • [Presentation] メタンフェタミン投与による自律生理反応でのオレキシン神経伝達物質グルタミン酸の役割2013

    • Author(s)
      生駒葉子, 宮田紘平, 桑木共之, 大塚曜一郎
    • Organizer
      第8回環境生理プレコングレス
    • Place of Presentation
      新宿
    • Year and Date
      2013-03-26
  • [Presentation] Ultradian Basic Rest-Activity Cycle in orexin deficient mice2012

    • Author(s)
      Miyata K, Ootsuka Y, Kuwaki T
    • Organizer
      Neuroscience 2012 (Society for Neuroscience)
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-17
  • [Presentation] Application of latest gene-engineered mice to autonomic neuroscience research2012

    • Author(s)
      Ootsuka Y
    • Organizer
      Collaborators Day 2012
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2012-09-28
    • Invited
  • [Presentation] 循環・呼吸・行動・摂食の超日リズムとオレキシン2012

    • Author(s)
      大塚曜一郎, 宮田紘平, 桑木共之
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-15
  • [Presentation] 睡眠・覚醒とエネルギー代謝の超日生体リズム2012

    • Author(s)
      大塚曜一郎
    • Organizer
      日本睡眠学会第37回定期学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-29
    • Invited
  • [Presentation] Methamphetamine causes considerable bradycardia in orexin knockout mice2012

    • Author(s)
      宮田紘平, 大塚曜一郎, 桑木共之
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-31
  • [Presentation] オレキシン欠損マウスでのメタアンフェタミンの心拍への効果2012

    • Author(s)
      大塚曜一郎, 宮田紘平, 桑木共之
    • Organizer
      第7回環境生理学プレコングレ
    • Place of Presentation
      長野
    • Year and Date
      2012-03-28
  • [Presentation] オレキシン神経機構の超日リズム形成への関与2011

    • Author(s)
      宮田紘平, 大塚曜一郎, 桑木共之
    • Organizer
      第62回西日本生理学会大会
    • Place of Presentation
      佐賀
    • Year and Date
      2011-10-14
  • [Presentation] Ultradian 90 min biological rhythm is attenuated in orexin-deficient mice2011

    • Author(s)
      Ootsuka, Y., Miyata, T, Kuwaki, T.
    • Organizer
      Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011
    • Place of Presentation
      Bouzios, Brazil
    • Year and Date
      2011-09-15
  • [Presentation] Ultradian rhythmicity in autonomic and behavioural parameters2011

    • Author(s)
      Blessing W.W., Ootsuka, Y.
    • Organizer
      Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011
    • Place of Presentation
      Bouzios, Brazil
    • Year and Date
      2011-09-15
  • [Presentation] The role of orexin in autonomic physiological response elicited by methamphetamine in mice2011

    • Author(s)
      Ootsuka, Y., Miyata, T, Kuwaki, T
    • Organizer
      Satellite Symposium for Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011
    • Place of Presentation
      Ouro Preto, Brazil
    • Year and Date
      2011-09-13
  • [Presentation] 循環・体温の超日リズム2011

    • Author(s)
      大塚曜一郎
    • Organizer
      第10回九州脳と高血圧研究会
    • Place of Presentation
      福岡
    • Year and Date
      2011-07-16

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Published: 2015-07-16  

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