2013 Fiscal Year Final Research Report
Integral control of circadian system by circadian protein phosphorylating oscillator
| Project/Area Number |
23590283
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | Circadian rhythm / Phosphorylation / Heat shock / Apoptosis / Anti-oxidant / Reactive oxygen species / Bioluminescence / stress |
|---|
| Research Abstract |
Circadian clock system integrates various physiological activities in whole body, and exhibits synchronizing properties as adaptive responses toward environments/ stresses. Thus, clock dysfunction become risk factors such for various lifestyle related diseases and cancer. This study examined time-specific and periodic regulatory system with CK2-orchestrated circadian protein phosphorylating oscillator. We elucidated circadian-oscillatory mechanism of CK2 activity and pivotal role of CK2 in integrating circadian system. Additionally, we found clock-synchronization by cell injury stresses, critical in disease processes, heat shock and reactive oxygen species, and integrative role of CK2 in the synergistic clock synchronization and the activation of stress-protective pathways, such as heat-shock response, anti-apoptotic and anti-oxidant pathways.
|
-
[Journal Article] ROS stress resets circadian clocks to coordinate pro-survival signals2013
Author(s)
Tamaru T, Hattori M, Ninomiya Y, Kawamura G, Varès G, Honda K, Mishra DP, Wang B, Benjamin I, Ozawa T, Takamatsu K
-
Journal Title
PLoS One
Volume: 8
Pages: e82006
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
