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2013 Fiscal Year Final Research Report

Study of natural resources improving the interaction between adipocytes and vascular endothelial cells

Research Project

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Project/Area Number 23590291
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKinki University

Principal Investigator

UESHIMA Shigeru  近畿大学, 農学部, 教授 (30193791)

Co-Investigator(Renkei-kenkyūsha) MATSUO Osamu  近畿大学, 医学部, 教授 (40030879)
OKADA Kiyotaka  近畿大学, 医学部, 講師 (20185432)
YAMASHITA Rina  近畿大学, 農学部, 助手 (90510876)
Project Period (FY) 2011 – 2013
Keywords脂肪細胞 / 血管内皮細胞 / 遊走 / 動脈硬化 / 肥満 / 天然資源物質
Research Abstract

Obesity is caused by the accumulation of oil into adipocytes and the deterioration factor for atherosclerosis. Angiogenesis induced by the migration of vascular endothelial (VE) cells is involved in acceleration of atherosclerosis. On the other hand, VE cells contribute to prevention of thrombogenesis. In this study, the natural resources which affect the interaction between adipocytes and VE cells were investigated. As a result, it was clarified that cyanidin-3-glucoside, natural pigments from black soy beans, and the humic substance inhibited the migration of VE cells in the presence of adipocytes. Moreover, it was demonstrated that the humic substance suppressed the progression of atherosclerosis and induced anti-thrombotic effect in animal model.

  • Research Products

    (15 results)

All 2014 2013 2012 2011

All Journal Article (5 results) Presentation (9 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Enzamin ameliorates adipose tissue inflammation with impaired adipocytokine expression and insulin resistance in db/db mice2013

    • Author(s)
      Tamura Y, Ueshima S, Matsuo O(他4名)
    • Journal Title

      J Nutr Sci

      Volume: 2 Pages: 1-10

    • DOI

      10.1017/jns.2013.34

  • [Journal Article] Lack of bothα2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production2013

    • Author(s)
      Okada K, Ueshima S, Matsuo O(他10名)
    • Journal Title

      Life Sci

      Volume: 93(2-3) Pages: 89-95

    • DOI

      10.1016/j.lfs.2013.05.023

  • [Journal Article] Alpha2-antiplasmin regulates the development of dermal fibrosis in mice by prostaglandin F(2α) synthesis through adipose triglyceride lipase/calcium-independent phospholipase A(2)2013

    • Author(s)
      Kanno Y, Okada K, Ueshima S, Matsuo O(他3名)
    • Journal Title

      Arthritis Rheum

      Volume: 65(2) Pages: 492-502

    • DOI

      10.1002/art.37767

  • [Journal Article] A synthetic peptide derived from staphylokinase enhances plasminogen activation by tissue-type plasminogen activator2011

    • Author(s)
      Okada K, Ueshima S, Matsuo O(他4名)
    • Journal Title

      J. Thromb Haemost

      Volume: 9(5) Pages: 997-1006

    • DOI

      10.1111/j.1538-7836.2011.04257.x

  • [Journal Article] Profibrinolytic effect of Enzamin, an extract of metabolic products from Bacillus subtilis AK and Lactobacillus2011

    • Author(s)
      Tamura Y, Okada K, Ueshima S, Matsuo O(他3名)
    • Journal Title

      J Thromb Thrombolysis

      Volume: 32(2) Pages: 195-200

    • DOI

      10.1007/s11239-011-0552-2

  • [Presentation] α2-アンチプラスミン/プラスミノーゲンアクチベータインヒビタタイプ1遺伝子欠損マウスは高IgE産生を示す2014

    • Author(s)
      岡田清孝, 上嶋繁
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2014-03-16
  • [Presentation] 脂肪細胞存在下における血管内皮細胞の遊走能に及ぼすアントシアニンの影響2013

    • Author(s)
      山下里奈, 上嶋繁
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2013-06-28
  • [Presentation] 新規合成ペプチドのプラスミノーゲン活性化および血栓溶解に対する促進作用2013

    • Author(s)
      岡田清孝, 上嶋繁, 松尾理
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2013-03-27
  • [Presentation] 血管内皮細胞の抗血栓性に影響する食物由来物質の探索2012

    • Author(s)
      山下里奈, 上嶋繁
    • Organizer
      第22回日本病態生理学会
    • Place of Presentation
      湯布院厚生年金病院(由布)
    • Year and Date
      2012-08-03
  • [Presentation] 褐藻類由来成分の抗血栓効果についての検討2012

    • Author(s)
      山下里奈, 上嶋繁
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2012-06-22
  • [Presentation] 虚血性脳傷害後に伴う血管透過性亢進の時間的および空間的な違いの検討2012

    • Author(s)
      永井信夫, 岡田清孝, 上嶋繁, 松尾理
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市総合体育館(長野)
    • Year and Date
      2012-03-30
  • [Presentation] 脂肪細胞と血管平滑筋細胞の共存下におけるアントシアニンの効果2011

    • Author(s)
      勇井克也, 山下里奈, 上嶋繁
    • Organizer
      第21回日本病態生理学会
    • Place of Presentation
      日本大学医学部(東京)
    • Year and Date
      2011-08-20
  • [Presentation] Potentiation of plasmin activity by enzamin, an extract of metabolite from Bacillus subtilis AK and Lactobacillus in vitro and in vivo2011

    • Author(s)
      Tamura Y, Okada K, Ueshima S, Matsuo O
    • Organizer
      The XXIII Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2011-07-26
  • [Presentation] A new synthetic peptide (sp) enhances plasminogen activation by t-PA2011

    • Author(s)
      Okada K, Ueshima S, Matsuo O
    • Organizer
      The XXIII Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2011-07-26
  • [Patent(Industrial Property Rights)] 海洋性腐植土の水性溶媒抽出物とその用途2011

    • Inventor(s)
      上嶋繁, 山下里奈, 勇井克也, 山本光章
    • Industrial Property Rights Holder
      学校法人近畿大学, 株式会社マリネックス
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特許出願2011-168358
    • Filing Date
      2011-08-01
    • Overseas

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Published: 2015-07-16  

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