2013 Fiscal Year Final Research Report

The elucidation of central chemosensitive respiratory regulation by TRP channels expressed in glial cell.

Research Project

Project/Area Number	23590292
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Hyogo Medical University
Principal Investigator	HIRATA Yutaka 兵庫医科大学, 医学部, 講師 (10441247)
Co-Investigator(Kenkyū-buntansha)	OKU Yoshitaka 兵庫医科大学, 医学部, 教授 (20252512) KUBO Shuji 兵庫医科大学, 医学部, 准教授 (10441320)
Project Period (FY)	2011 – 2013
Keywords	TRP / 中枢性呼吸調節 / グリア細胞 / 二酸化炭素 / 延髄
Research Abstract	The central chemosensitive respiratory regulation in medulla of brainstem is important in the maintenance of blood gas and pH homeostasis. We reported that transient receptor potential (TRP) channel family was involved in hypercapnic Ca responses in medullary glial cells. To identify the subtype of the TRP channels as central chemosensing molecules, we detected the expression pattern of TRP channel family in medullary glial cells. TRP-X subtype channel is highest expression in medullary glial cells. In comparison with wild-type mice, the effects of ventilation response to 8%CO2 on TRP-X knockout mice attenuated. These results suggest that the TRP-X channel is involved in the central chemosensitive respiratory regulation.