2013 Fiscal Year Final Research Report
Analysis of sex differences in cardiovascular development
| Project/Area Number |
23590297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUROKAWA Junko 東京医科歯科大学, 難治疾患研究所, 准教授 (40396982)
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| Co-Investigator(Renkei-kenkyūsha) |
西山 功 熊本大学, 付属病院, 特任講師 (80398221)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 循環器 / 性差 / 心臓 / 発生 / 冠血管 / マウス / 発現解析 |
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| Research Abstract |
Cardiovascular disease (CVD) affects men at younger age than women, which has been attributed to the loss of estrogen after menopause. However, recent clinical and basic studies unravel that the underlying mechanisms seem unlikely to be due to estrogen only and are more complex. Although it is well established that aging is a risk factor for CVDs, many of the molecular pathways involved in CVDs have roots in cardiac developmental programs. Thus, we here seek biological sex differences in cardiovascular development of murine hearts to obtain clues to elucidate the sex differences in CVDs. We found sex differences in morphological and physiological functions of coronary arteries in murine hearts at embryonic day 17.5, and the differece was abolished by vasodilators. These results suggest that sex differences in coronary arteries exist at a late embryonic stage in mice.
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