2013 Fiscal Year Final Research Report
Degradation of cation channel and the dysfunction
| Project/Area Number |
23590312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HATANO Noriyuki 愛知学院大学, 薬学部, 講師 (50454319)
SUZUKI Hiroka 愛知学院大学, 薬学部, 助教 (00581026)
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| Project Period (FY) |
2011 – 2013
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| Keywords | チャネル / タンパク発現制御 / 炎症 |
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| Research Abstract |
In this research project, we have found that TRPA1 channel, a subfamily of TRP cation channel, is substantially induced by inflammatory stimuli in channel-expression and channel-function levels; a transcriptiona factor, which is activated in hypoxia, is involved in the induction and TRPA1 gene promoter has a specific binding site of the factor. Because TRPA1 channel is involved in nociception, the present finding may contribute to developement of novel drugs for inflammatory nociception.
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