2013 Fiscal Year Final Research Report
Regulation of tumor angiogenesis and metastasis, and postischemic angiogenesis by sphingosine-1-phosphate signaling system
| Project/Area Number |
23590344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Ishikawa Prefectural Nursing University |
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Principal Investigator |
TAKUWA Noriko 石川県立看護大学, 看護学部, 教授 (70150290)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脂質メディエーター / がん血管新生 / 虚血後血管新生 / スフィンゴシンキナーゼ / G蛋白共役型受容体 |
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| Research Abstract |
The sphingosine-1-phosphate receptor S1PR2 is the first G protein-coupled receptor that negatively regulates cell migration through inhibition of Rac downstream of G12/13-Rho. S1PR2 expressed in tumor cells mediates inhibition of cell migration and invasion in vitro and hematogenous metastasis in vivo. S1PR2 expressed in host vascular endothelial cells and bone marrow-derived myeloid cells together mediate inhibition of tumor angiogenesis and tumor growth in vivo. We studied the roles of host S1PR2 in metastasis and post-ischemic angiogenesis and found interesting results. We also tested a widely accepted concept that sphingosine kinase 1 (SphK1), a major S1P synthesizing enzyme, plays an causative role in cancer development, by comparing incidence of malignancies between SphK1 transgenic mice and their littermates. We found no difference in incidence of either spontaneous or ENU (a mutagen)-induced tumor development between SphK1 transgenic and littermate wild type mice.
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[Presentation] スフィンゴシン1-リン酸特異的2型受容体は内皮型一酸化窒素合成酵素を抑制することによりアナフィラキシーショックに対して保護的に働く2013
Author(s)
崔弘, 岡本安雄, 吉岡和晃, 杜娃, 多久和典子, 張威, Kuntal Biswas, 安藝翔, 趙娟娟, 九田裕一, 浅野雅秀, 芝本利重, 多久和陽
Organizer
第90回日本生理学会
Place of Presentation
タワーホール船堀(東京)
Year and Date
20130327-29
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