2013 Fiscal Year Final Research Report
Significance of nuclear expression of mitochondrial transcription factor mtTFA and elucidation of stress resistance
| Project/Area Number |
23590351
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
IZUMI Hiroto 産業医科大学, 産業生態科学研究所, 准教授 (50289576)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMAJIRI Shohei 産業医科大学, 医学部, 准教授 (30320344)
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| Project Period (FY) |
2011 – 2013
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| Keywords | mtTFA / 遺伝子発現 / 転写因子 / 抗アポトーシス / ストレス耐性 |
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| Research Abstract |
mtTFA synthesized from TFAM (transcription factor A, mitochondrial) gene translocates to mitochondrion and regulates various gene expressions. In this study, we found that mtTFA was also present in not only mitochondrion but also nucleus, mtTFA regulated anti-apoptotic gene expressions such as BIRC5 (Survivin) and BCL2L1 (BCL-xL) at the transcriptional level, the growth of cancer cells was closely correlated with the expression of mtTFA and the nuclear expression of mtTFA was a poor prognostic factor in serous ovarian cancer. These findings suggest that mtTFA might function as anti-apoptosis through gene expressions. Molecular mtTFA targeted therapy might contribute to cancer treatment.
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[Journal Article]2011
Author(s)
Han B, Izumi H, Yasuniwa Y, Akiyama M, Yamaguchi T, Fujimoto N, Matsumoto T, Wu B, Tanimoto A, Sasaguri Y, Kohno K
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Journal Title
Biochem Biophys Res Commun
Volume: 29;408(1)
Pages: 45-51
DOI
Peer Reviewed
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