Studies on the novel factor in the renin-angiotensin system in the pathophysiology of the cardio-renal anemia syndrome

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590352
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Kazuhiro 東北大学, 医学(系)研究科(研究院), 教授 (80241628)
• Co-Investigator(Kenkyū-buntansha): 戸恒 和人 東北福祉大学, 総合福祉学部, 教授 (10217515) ; 金子 桐子 東北大学, 大学院医学系研究科, 助教 (10545784)
• Project Period (FY): 2011 – 2013
• Keywords: プロレニン受容体 / 赤芽球 / インターフェロン-γ / エリスロポエチン / トリヨードサイロニン / 腎性貧血 / トリヨードサイロニン

Research Abstract

Prorenin receptor is a specific receptor for renin and prorenin. We have shown expression of prorenin receptor in cultured erythroid cells, YN-1 cells and YN-1-0A cells. Interferon-gamma, erythropoietin and triiodothyronine affected its expression levels. Prorenin receptor stimulates cell proliferation. These findings have raised the possibility that prorenin receptor is related to erythropoiesis and may play some pathophysiological roles in anemia, such as renal anemia.

Research Products

• [Journal Article] Expression of (pro)renin receptor in breast cancers and its effect on cancer cell proliferation (2014)
  • Author(s): Ohba K, Suzuki T, Nishiyama H, Kaneko K, Hirose T, Totsune K, Sasano S, Takahashi K
  • Journal Title: Biomed Res (Tokyo) Volume: 35 Pages: 117-126
  • URL: https://www.jstage.jst.go.jp/browse/biomedres
  • Peer Reviewed
• [Journal Article] Increased expression of (pro)renin receptor in aldosterone-producing adenomas (2013)
  • Author(s): Yamamoto H, Kaneko K, Ohba K, Morimoto R, Hirose T, Satoh F, Totsune K, Takahashi K
  • Journal Title: Peptides Volume: 49 Pages: 68-73
  • DOI: 10.1016/j.peptides.2013.08.022
  • Peer Reviewed
• [Journal Article] In situ hybridization method reveals (pro)renin receptor expressing cells in the pituitary gland of rats:Correlation with anterior pituitary hormones (2013)
  • Author(s): Takahashi K, Yatabe M, Fujiwara K, Hirose T, Totsune K, Yashiro T
  • Journal Title: Acta Histochem Cytochem Volume: 46 Pages: 47-50
  • DOI: 10.1267/ahc.12030
  • Peer Reviewed
• [Journal Article] Expression of (pro)renin receptor in human erythroid cell lines and its increased protein accumulation by interferon-γ (2012)
  • Author(s): Kaneko K, Nishiyama H, Ohba K, Shibasaki A, Hirose T, Totsune K, Furuyama K, Takahashi K
  • Journal Title: Peptides Volume: 37 Pages: 285-289
  • DOI: 10.1016/j.peptides.2012.07.015
  • Peer Reviewed
• [Journal Article] Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women:the Ohasama study (2011)
  • Author(s): Hirose T, Hashimoto M, Totsune K, Metoki H, Hara A, Satoh M, Kikuya M, Ohkubo T, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y
  • Journal Title: Hypertens Res Volume: 34 Pages: 530-535
  • DOI: 10.1038/hr.2010.274
  • Peer Reviewed
• [Presentation] (Pro)renin receptor in the breast cancer and its possible pathophysiological role in cancer cell proliferation (2013)
  • Author(s): Takahashi K, Ohba K, Nishiyama H, Kaneko K, Hirose T, Totsune K, Sasano H, Suzuki T
  • Organizer: 13th International Conference on Endothelin
  • Place of Presentation: 東京
  • Year and Date: 20130908-11
• [Presentation] Role of (pro)renin receptor in cell proliferation (2013)
  • Author(s): Ohba K, Nishiyama H, Kaneko K, Hirose T, Totsune K, Takahashi K
  • Organizer: The 37th World Congress of the International Union of Physiological Sciences (IUPS 2013)
  • Place of Presentation: Birmingham, UK
  • Year and Date: 20130721-26
• [Presentation] Effect of triiodothyronine and erythropoietin on expression of (pro)renin receptor in the human erythroid cell line, YN-1 (2013)
  • Author(s): Nishiyama H, Kaneko K, Ohba K, Hirose T, Totsune K, Takahashi K
  • Organizer: International symposium of aldosterone and related substances in hypertension 2013 (ISARSH2013)
  • Place of Presentation: 仙台
  • Year and Date: 20130427-28
• [Presentation] (Pro)renin receptor in breast carcinoma (2013)
  • Author(s): Ohba K, Nishiyama H, Kaneko K, Hirose T, Totsune K, Sasano H, Suzuki T, Takahashi K
  • Organizer: International symposium of aldosterone and related substances in hypertension 2013 (ISARSH2013)
  • Place of Presentation: 仙台
  • Year and Date: 20130427-28
• [Presentation] High expression of (pro)renin receptor in tumor tissues of aldosterone-producing adrenocortical adenomas (2013)
  • Author(s): Yamamoto H, Kaneko K, Ohba K, Morimoto R, Hirose T, Satoh F, Totsune K, Takahashi K
  • Organizer: International symposium of aldosterone and related substances in hypertension 2013 (ISARSH2013)
  • Place of Presentation: 仙台
  • Year and Date: 20130427-28
• [Presentation] 赤芽球系細胞YN-1におけるプロレニン受容体の発現の検討:エリスロポエチンとトリヨードサイロニンの効果 (2013)
  • Author(s): 西山浩史, 金子桐子, 大場浩史, 廣瀬卓男, 戸恒和人, 高橋和広
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 20130425-27
• [Presentation] 赤芽球系細胞YN-1におけるプロレニン受容体の発現:プロレニン受容体の造血への関与の示唆 (2013)
  • Author(s): 西山浩史, 大場浩史, 金子桐子, 宍戸夕記, 高橋日和, 廣瀬卓男, 戸恒和人, 高橋和広
  • Organizer: 第42回日本心脈管作動物質学会
  • Place of Presentation: 奈良
  • Year and Date: 20130208-09
• [Presentation] 赤芽球系細胞YN-1におけるプロレニン受容体の発現の検討:トリヨードサイロニンの効果 (2012)
  • Author(s): 西山浩史, 金子桐子, 大場浩史, 廣瀬卓男, 戸恒和人, 高橋和広
  • Organizer: 第16回日本心血管内分泌代謝学会
  • Place of Presentation: 東京
  • Year and Date: 20121123-24
• [Presentation] Effect of triiodothyronine and angiotensin-II on expression of (pro)renin receptor in the human erythroid cell line, YN-1 (2012)
  • Author(s): Nishiyama H, Kaneko K, Ohba K, Yoshioka T, Shimizu T, Hirose T, Totsune K, Takahashi K
  • Organizer: 15th International Congress of Endocrinology and 14th European Congress of Endocrinology
  • Place of Presentation: Florence, Italy
  • Year and Date: 20120505-09
• [Presentation] Expression of (pro)renin receptor in human erythroid cell lines:the effect of interferon-gamma (2011)
  • Author(s): Kaneko K, Shibasaki A, Nishiyama H, Hirose T, Ohba K, Totsune K, Furuyama K, Takahashi K
  • Organizer: 53rd American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20111210-13
• [Presentation] ヒト赤芽球系培養細胞におけるプロレニン受容体の発現:interferon-γの効果 (2011)
  • Author(s): 金子桐子, 柴崎瑛子, 廣瀬卓男, 大場浩史, 西山浩史, 戸恒和人, 高橋和広
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 20110921-24
• [Book] Urotensin peptides. In Handbook of Biologically Active Peptides Second Edition. Kastin AJ, ed. (2013)
  • Author(s): Takahashi K, Totsune K
  • Total Pages: 1437-1442
  • Publisher: Elsevier, Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo
• [Remarks]
  • URL: http://www.med.tohoku.ac.jp/org/health/81/index.html