2013 Fiscal Year Final Research Report
Regulatory mechanisms for heme biosynthesis in response to the change of regulatory heme pool.
| Project/Area Number |
23590353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Iwate Medical University (2013)
Tohoku University (2011-2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIBAHARA Shigeki 東北大学, 大学院医学系研究科, 教授 (00154253)
KANEKO Kiriko 東北大学, 大学院医学系研究科, 助教 (10545784)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヘム / 翻訳後修飾 / ミトコンドリア / 5-アミノレブリン酸合成酵素 |
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| Research Abstract |
Heme is an essential prosthetic group of several proteins, and is synthesized in all living cells. On the other hand, production of heme was strictly regulated in each cells, since excess amount of heme produces reactive oxygen spices. It has been well known that the expression of non-specific 5-aminolevulinate synthase (ALAS1), which is the first and the rate limiting enzyme of heme biosynthetic pathway in non-erythroid cells, is regulated at transcriptional, as well as at several post-transcriptional levels for the strict regulation of heme biosynthesis. In the present project, we have challenged to determine the novel mechanisms, which is involved in the precise and quick response of ALAS1 expression to the change of heme contents in the cells.As a result, we have successfully identified novel mechanisms for post-translational regulation of ALAS1 protein in mitochondria.
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Research Products
(15 results)
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[Journal Article] Clinical and genetic characteristics of congenital sideroblastic anemia : comparison with myelodysplastic syndrome with ring sideroblast (MDS-RS)2013
Author(s)
Ohba R, Furuyama K, Yoshida K, Fujiwara T, Fukuhara N, Onishi Y, Manabe A, Ito E, Ozawa K, Kojima S, Ogawa S, Harigae H
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Journal Title
Ann Hematol
Volume: 92(1)(PMID : 22983749; PMCID : PMC3536986)
Pages: 1-9
DOI
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