2013 Fiscal Year Final Research Report
Search for biomarkers of central nervous system diseases that show subtle morphological changes on MRI and CT.
| Project/Area Number |
23590367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIROTANI Keiro 長崎大学, 大学院医歯薬総合研究科, 准教授 (20322696)
KARIYA Yoshinobu 福島県立医科大学, 生化学講座, 准教授 (00458217)
NARA Kiyomitsu 福島県立医科大学, 生化学講座, 講師 (40260327)
ITO Hiromi 福島県立医科大学, 生化学講座, 助教 (00450669)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アルツハイマー病 / 軽度認知障害 / 診断マーカー / 髄液 |
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| Research Abstract |
Alzheimer disease (AD) is diagnosed by dementia and brain atrophy. For effective treatment of AD, we need novel diagnostic markers for early stage of AD, which shows subtle morphological changes. In cerebrospinal fluid, we found 17 kinds of glycoproteins that carried glycans unique to the brain (brain-type glycan). By immunoblotting, some of the glycoproteins were examined whether they were diagnostic markers for AD or not, but none of them was the marker. It is noted that glycoproteins often include several isoforms, which have different glycans on the same core-protein (glycan-isoforms). These glycan-isoforms are not discriminated by immunoblotting, because conventional antibodies recognize core-protein portion but not glycan one. We have recently established a method for discriminating glycan-isoforms, which would be applicable to the glycoproteins in cerebrospinal fluid of AD.
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