2014 Fiscal Year Final Research Report
Regulation of CXCR7 expression and function in tumors and inflammation.
| Project/Area Number |
23590372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Miyagi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIE Osamu 近畿大学, 医学部, 教授 (10166910)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | CXCR7 / 発現 / 乳がん / ケモカイン |
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| Outline of Final Research Achievements |
Chemokine receptor, CXCR7, which is expressed by various tumors, such as breast and lung tumors, has important rules and promotes tumorigenesis and tumor growth. In this study, microarray analysis was performed for breast tumor cells treated with CXCR7 inhibitor CCX771, to investigate the regulation of CXCR7 expression and function.
As a result, it revealed that CXCR7 promoted breast tumor cell growth and/or survival. Microarray analysis indicated that polycomb group protein, extracellular protease, apoptosis related genes were elevated in CCX771 treatment. It is important to elucidate the role of polycomb group protein in regulation of CXCR7 expression and function.
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| Free Research Field |
免疫学、食品免疫学
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