Genome-wide association study of high myopia using multiple ethnic groups

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590382
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human genetics
• Research Institution: Yokohama City University
• Principal Investigator: NOMURA Naoko 横浜市立大学, 医学部, 助教 (40537205)
• Co-Investigator(Kenkyū-buntansha): MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579) ; MEGURO Akira 横浜市立大学, 医学研究科, 特任講師 (60508802) ; KAWAGOE Tatsutaka 横浜市立大学, 医学部, 助教 (20564800)
• Project Period (FY): 2011 – 2013
• Keywords: 近視 / 遺伝子

Research Abstract

In this study, we performed a genome-wide association study (GWAS) of high myopia using multiple ethnic groups (Japanese, Taiwanese, Chinese, Chinese Singaporean) and identified two genetic loci showing a significant association with the risk of high myopia in all ethnic groups. Our genetic findings may lead to clarify a pathogenic mechanism of high myopia.

Research Products

• [Journal Article] Association study of fibroblast growth factor 10 (FGF10) polymorphisms with susceptibility to extreme myopia in a Japanese population (2013)
  • Author(s): Yoshida M, Meguro A, Okada E, Nomura N, Mizuki N
  • Journal Title: Mol Vis Volume: 19 Pages: 2321-2329
  • URL: http://www.molvis.org/molvis/v19/2321/mv-v19-2321.pdf
  • Peer Reviewed
• [Journal Article] Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population (2013)
  • Author(s): Yoshida M, Meguro A, Yoshino A, Nomura N, Okada E, Mizuki N
  • Journal Title: Clin Ophthalmol Volume: 7 Pages: 2057-2062
  • DOI: 10.2147/OPTH.S52726
  • Peer Reviewed
• [Journal Article] Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error (2013)
  • Author(s): Meguro A, Mizuki N(他106名)
  • Journal Title: Am J Hum Genet Volume: 93(2) Pages: 264-277
  • DOI: 10.1016/j.ajhg.2013.06.016
  • Peer Reviewed
• [Journal Article] Dogs and Humans Share a Common Susceptibility Gene SRBD1 for Glaucoma Risk (2013)
  • Author(s): Kanemaki N, Tchedre KT, Imayasu M, Kawarai S, Sakaguchi M, Yoshino A, Itoh N, Meguro A, Mizuki N
  • Journal Title: PLoS One Volume: 8(9) Pages: e74372
  • DOI: 10.1371/journal.pone.0074372
  • Peer Reviewed
• [Journal Article] Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population (2013)
  • Author(s): Meguro A, Mizuki N(他28名)
  • Journal Title: Eye (Lond) Volume: 27(8) Pages: 979-983
  • DOI: 10.1038/eye.2013.123
  • Peer Reviewed
• [Journal Article] Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behcet disease (2013)
  • Author(s): Mizuki N, Meguro A(他24名)
  • Journal Title: Proc Natl Acad Sci U S A Volume: 110(20) Pages: 8134-8139
  • DOI: 10.1073/pnas.1306352110
  • Peer Reviewed
• [Journal Article] Investigation of the Association Between Toll-like Receptor 9 Gene Polymorphisms and Sarcoidosis in Japanese Patients (2013)
  • Author(s): Yotsumoto S, Meguro A, Ishihara M, Uemoto R, Ota M, Morimoto SI, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
  • Journal Title: Ocul Immunol Inflamm Volume: 21(3) Pages: 234-236
  • DOI: 10.3109/09273948.2012.756114
  • Peer Reviewed
• [Journal Article] Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population (2013)
  • Author(s): Mikami T, Meguro A, Teshigawara T, Takeuchi M, Uemoto R, Kawagoe T, Nomura E, Asukata Y, Ishioka M, Iwasaki M, Fukagawa K, Konomi K, Shimazaki J, Nishida T, Mizuki N
  • Journal Title: Mol Vis Volume: 19 Pages: 845-851
  • URL: http://www.molvis.org/molvis/v19/845/mv-v19-845.pdf
  • Peer Reviewed
• [Journal Article] Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1 (2013)
  • Author(s): Mizuki N, Meguro A(他22名)
  • Journal Title: Nat Genet Volume: 45(2) Pages: 202-207
  • DOI: 10.1038/ng.2520
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease (2013)
  • Author(s): Meguro A, Mizuki N(他18名)
  • Journal Title: Ann Rheum Dis Volume: 72(9) Pages: 1510-1516
  • DOI: 10.1136/annrheumdis-2011-200288
  • Peer Reviewed
• [Journal Article] Genetic Characterization and Susceptibility for Sarcoidosis in Japanese Patients : Risk Factors of BTNL2 Gene Polymorphisms and HLA Class II Alleles (2012)
  • Author(s): Meguro A, Kawagoe T, Mizuki N(他21名)
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53(11) Pages: 7109-7115
  • DOI: 10.1167/iovs.12-10491
  • Peer Reviewed
• [Journal Article] Common variants in the COL4A4 gene confer susceptibility to lattice degeneration of the retina (2012)
  • Author(s): Meguro A, Kawagoe T, Mizuki N(他14名)
  • Journal Title: PLoS One Volume: 7(6) Pages: e39300
  • DOI: 10.1371/journal.pone.0039300
  • Peer Reviewed
• [Journal Article] Genetic variants on chromosome 1q41 influence ocular axial length and high myopia (2012)
  • Author(s): Meguro A, Mizuki N(他28名)
  • Journal Title: PLoS Genet Volume: 8(6) Pages: e1002753
  • DOI: 10.1371/journal.pgen.1002753
  • Peer Reviewed
• [Journal Article] Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients (2012)
  • Author(s): Meguro A, Mizuki N(他15名)
  • Journal Title: Mol Vis Volume: 18 Pages: 512-518
  • URL: http://www.molvis.org/molvis/v18/a56/mv-v18-a56-sakuyama.pdf
  • Peer Reviewed
• [Journal Article] Confirmation of TBK1 duplication in normal tension glaucoma (2012)
  • Author(s): Kawase K, Allingham RR, Meguro A, Mizuki N, Roos B, Solivan-Timpe FM, Robin AL, Ritch R, Fingert JH
  • Journal Title: Exp Eye Res Volume: 96(1) Pages: 178-180
  • DOI: 10.1016/j.exer.2011.12.021
  • Peer Reviewed
• [Journal Article] Factors associated with enlargement of chorioretinal atrophy after intravitreal bevacizumab for myopic choroidal neovascularization (2012)
  • Author(s): Uemoto R, Nakasato-Sonn H, Kawagoe T, Meguro A, Okada E, Mizuki N
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 250(7) Pages: 989-997
  • DOI: 10.1007/s00417-011-1921-4
  • Peer Reviewed
• [Journal Article] Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population (2012)
  • Author(s): Horie Y, Meguro A, Kitaichi N, Lee EB, Kanda A, Noda K, Song YW, Park KS, Namba K, Ota M, Inoko H, Mizuki N, Ishida S, Ohno S
  • Journal Title: Rheumatology (Oxford) Volume: 51(6) Pages: 983-986
  • DOI: 10.1093/rheumatology/ker444
  • Peer Reviewed
• [Journal Article] Anatomical and functional changes of retina following subretinal injection of high-speed fluid (2012)
  • Author(s): Uemoto R, Nakasato-Sonn H, Meguro A, Okada E, Mizuki N
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 250(3) Pages: 447-450
  • DOI: 10.1007/s00417-011-1800-z
  • Peer Reviewed