2013 Fiscal Year Final Research Report
Significance of DNA damage response in cancerization in ulcerative colitis
| Project/Area Number |
23590391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WAKAI Toshifumi 新潟大学, 医歯学系, 教授 (50372470)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 炎症性発癌 / 潰瘍性大腸炎 / 大腸癌 / DNA二重鎖切断 / DNA損傷応答 / 免疫組織化学 / dysplasia |
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| Research Abstract |
Inflammatory mucosa in ulcerative colitis showed elevated level of DNA damages (DNA double strand breaks) and cancerization in UC may be prepared in such DNA damaged mucosa. Invasive carcinoma in ulcerative colitis showed significantly low level of DNA damage response than early phase of cancerization process. In comparison with sporadic tumors, invasive carcinoma in ulcerative colitis showed significantly low level of DNA damage response. By these data, it is speculated that DNA damages and early failure of DNA damage responese may occurred during inflammatory cancerization process in UC.
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Research Products
(12 results)
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[Journal Article] RUNX3 copy number predicts the development of UC-associated colorectal cancer2011
Author(s)
Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iimura H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
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Journal Title
International Journal of Oncology
Volume: 38
Pages: 201-2077
DOI
Peer Reviewed
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