2013 Fiscal Year Final Research Report
Analysis of M2 macrophage/cancer interaction in carcinogenesis, growth and progression of human esophageal squamous cell carcinoma
Project/Area Number |
23590397
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Kobe University |
Principal Investigator |
YOKOZAKI Hiroshi 神戸大学, 医学(系)研究科(研究院), 教授 (10200891)
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Project Period (FY) |
2011 – 2013
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Keywords | 病理学 / 癌 / 食道 / マクロファージ / 癌・間質相互作用 |
Research Abstract |
Infiltration of M2 type macrophage in human esophageal squamous cell carcinomas (ESCCs) was associated with grade of malignancy and patients prognosis. Cyr61, extracted as one of the up-regulated genes during M2 differentiation of THP-1 human monocytic leukemia cell line by conditioned media of ESCC cell lines, induced expression of CD204 and migration of macrophages through activation of MEK/Erk signal pathways. GDF15, from activated human peripheral blood monocyte derived macrophage, promoted growth of ESCC cells by activating Akt and Erk. Activated macrophages promoted the growth of immortalized normal human esophageal squamous epithelial cells.
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[Journal Article] Clinicopathological characteristics of abnormal micro-lesions at the oro-hypopharynx detected by a magnifying narrow band imaging system2012
Author(s)
Tanaka S, Morita Y, Fujita T, Yokozaki H, Obata D, Fujiwara S, Wakahara C, Masuda A, Sugimoto M, Sanuki T, Yoshida M, Toyonaga T, Kutsumi H, Azuma T
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Journal Title
Dig Endosc
Volume: 24巻
Pages: 100−109
DOI
Peer Reviewed
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[Presentation] Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells2013
Author(s)
Urakawa N, Takase N, Shigeoka N, Nishio M, Watajima T, Utsunomiya S, Yashiro M, Hirakawa K, Koma Y, Semba S, Yanagihara K, Suzuki S, Kakeji Y, Yokozaki H
Organizer
The 4th JCA-AACR Special Joint Conference : The Latest Advances in Gastric Cancer Research
Place of Presentation
東京ベイ舞浜ホテル(浦安市)
Year and Date
20131216-18
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[Presentation] 食道上皮内マクロファージ密度と上皮増殖性病変分布の相関2013
Author(s)
横崎宏, 森田康枝, 藤原もも, 中鉢亜弥, 深澤圭似子, 重岡学, 西尾真理, 裏川直樹, 綿島健人, 狛雄一朗, 仙波秀峰
Organizer
第102回日本病理学会総会
Place of Presentation
ロイトン札幌(札幌市)
Year and Date
2013-06-07
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