Molecular and pathological analysis of transfromation of follicular lymphoma

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590398
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Okayama University
• Principal Investigator: YOSHINO Tadashi 岡山大学, 医歯(薬)学総合研究科, 教授 (70183704)
• Co-Investigator(Kenkyū-buntansha): OKA Takashi 岡山大学, 大学院医歯薬学総合研究科, 助教 (50160651)
• Research Collaborator: 高田 尚良 岡山大学, 大学院医歯薬学総合研究科, 助教 (90580259)
• Project Period (FY): 2011 – 2013
• Keywords: 悪性リンパ腫 / 濾胞性リンパ腫 / 高悪性度化

Research Abstract

We focused on the follicular dendrici cell meshwork for examining the transformation of follicular lymphoma. Duodenal follicular lymphoma which is a subtype of rare transformation lacks dendritic cell meshwork, but nodal follicular lymphoma has dense meshwork. Furthermore, duodenal follicular lymphoma has memory B cell characteristics and it suggested that tumor cell origin is important for transformation (Mod Pathol 2013). From the comprehensive gene expression analysis, nodal follicular lymphoma had different characteristics from duodenal follicular lymphoma, and cytokine-related genes and adhesion molecule was important for tumorigenesis. (Cancer Sci 2014)

Research Products

• [Journal Article] Clinicopathological analysis of 17 primary cutaneous T-cell lymphoma of theγδphenotype from Japan (2014)
  • Author(s): Takahashi Y, Takata K, Kato S, Sato Y, Asano N, Ogino T, Hashimoto K, Tashiro Y, Takeuchi S, Masunari T, Hiramatsu Y, Maeda Y, Tanimoto M, Yoshino T
  • Journal Title: Cancer Sci Volume: (Epub ahead of print)
  • DOI: 10.1111/cas.12439
  • Peer Reviewed
• [Journal Article] Low-grade B-cell lymphoma presenting primarily in the bone marrow (2014)
  • Author(s): Iwatani K, Takata K, Sato Y, Miyata-Takata T, Iwaki N, Cui W, Sawada-Kitamura S, Sonobe H, Tamura M, Saito K, Miyatani K, Yamasaki R, Yamadori I, Fujii N
  • Journal Title: Hum Pathol Volume: (Epub ahead of print)
  • DOI: 10.1016/j.humpath.2014.02.010
  • Peer Reviewed
• [Journal Article] Duodenal follicular lymphoma : Comprehensive gene expression analysis with insights into pathogenesis (2014)
  • Author(s): Takata K, Tanino M, Ennishi D, Tari A, Sato Y, Okada H, Maeda Y, Goto N, Araki H, Harada M, Ando M, Iwamuro M, Tanimoto M, Yamamoto K
  • Journal Title: Cancer Sci Volume: 105 Pages: 608-615
  • DOI: 10.1111/cas.12392
  • Peer Reviewed
• [Journal Article] Detection of T-cell receptorγgene rearrangement in paraffin-embedded T or natural killer/T-cell lymphoma samples using the BIOMED-2 protocol (2014)
  • Author(s): Miyata-Takata T, Takata K, Yamanouchi S, Sato Y, Harada M, Oka T, Tanaka T, Maeda Y, Tanimoto M, Yoshino T
  • Journal Title: Leukemia Lymphoma Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] In aggressive variants of non-Hodgkin lymphomas, Ezh2 is strongly expressed and polycomb repressive complex PRC1.4 dominates over PRC1.2 (2013)
  • Author(s): Abd Al Kader L, Oka T, Takata K, Sun X, Sato H, Murakami I, Toji T, Manabe A, Kimura H, Yoshino T
  • Journal Title: Virchows Archivs Volume: 463 Pages: 697-711
  • DOI: 10.1007/s00428-013-1428-y
  • Peer Reviewed
• [Journal Article] Distinct morphologic, phenotypic, and clinical-course characteristics of indolent peripheral T-cell lymphoma (2013)
  • Author(s): Hayashi E, Takata K, Sato Y, Tashiro Y, Tachiyama Y, Sawada-Kitamura S, Hiramatsu Y, Sugiguchi S, Nose S, Hirokawa M, Ando M, Abd Alkader L, Maeda Y, Tanimoto M, Yoshino T
  • Journal Title: Hum Pathol Volume: 44 Pages: 1927-1936
  • DOI: 10.1016/j.humpath.2013.03.002
  • Peer Reviewed
• [Journal Article] Clinicopathologic analysis of localized nasal/paranasal diffuse large B-cell lymphoma (2013)
  • Author(s): Toda H, Sato Y, Takata K, Orita Y, Asano N, Yoshino T
  • Journal Title: PLoS One Volume: 8 Pages: e57677
  • DOI: 10.1371/journal.pone.0057677
  • Peer Reviewed
• [Journal Article] A20 (TNFAIP3) deletion in Epstein-Barr virus-associated lymphoproliferative disorders/lymphomas (2013)
  • Author(s): Ando M, Sato Y, Takata K, Nomoto J, Nakamura S, Ohshima K, Takeuchi T, Orita Y, Kobayashi Y, Yoshino T
  • Journal Title: PLoS One Volume: 8 Pages: e56741
  • DOI: 10.1371/journal.pone.0056741.
  • Peer Reviewed
• [Journal Article] Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics (2013)
  • Author(s): Takata K, Sato Y, Nakamura N, Tokunaka M, Miki Y, Yukie Kikuti Y, Igarashi K
  • Journal Title: Mod Pathol Volume: 26 Pages: 22-31
  • DOI: 10.1038/modpathol.2012.127
  • Peer Reviewed
• [Journal Article] Pathological Diagnosis (2012)
  • Author(s): Yoshino T, Takata K
  • Journal Title: Nihon Rinsho Volume: 70 Pages: 193-7
• [Journal Article] Germinal center B-cell-like diffuse large B-cell lymphoma of the duodenum is associated with t(14;18) translocation (2011)
  • Author(s): Tamura M, Takata K, Sato Y, Nakamura N, Kikuti YY, Ichimura K, Tanaka T, Tari A, Maeda Y, Tanimoto M, Okada H, Yoshino T
  • Journal Title: Pathol Int Volume: 61 Pages: 42-8
  • DOI: 10.1111/j.1440-1827.2011.02748.x.
  • Peer Reviewed
• [Journal Article] Nodal follicular lymphoma without complete follicular dendritic cell networks is related to localized clinical stage (2011)
  • Author(s): Cui W, Che L, Sato Y, Huang X, Takata K, Orita Y, Goto N, Maeda Y, Tanimoto M, Yoshino T
  • Journal Title: Pathol Int Volume: 61 Pages: 737-741
  • DOI: 10.1111/j.1440-1827.2011.02736.x
  • Peer Reviewed
• [Journal Article] Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity : a multicenter, retrospective analysis in Japan (2011)
  • Author(s): Takata K, Okada H, Ohmiya N, Nakamura S, Kitadai Y, Tari A, Akamatsu T, Kawai H, Tanaka S, Araki H, Yoshida T, Okumura H, Nishisaki H, Sagawa T, Watanabe N, Arima N, Takatsu N, Nakamura M, Yanai S, Kaya H, Morito T, Sato Y, Moriwaki H, Sakamoto C, Niwa Y, Goto H, Chiba T, Matsumoto T, Ennishi D, Kinoshita T, Yoshino T
  • Journal Title: Cancer Sci Volume: 102 Pages: 1532-6
  • DOI: 10.1111/j.1349-7006.2011.01980.x.
  • Peer Reviewed
• [Presentation] 皮膚原発γδT細胞リンパ腫の臨床病理学的解析 (2013)
  • Author(s): 高田尚良, 高橋友香, 加藤省一, 谷本光音, 吉野正
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-05
• [Presentation] 消化管濾胞性リンパ腫の最新知見 (2013)
  • Author(s): 高田尚良, 吉野正
  • Organizer: 日本病理学会ワークショップ
  • Place of Presentation: 札幌
  • Year and Date: 20130606-08
• [Presentation] 悪性リンパ腫の病理形態と分子形態 (2012)
  • Author(s): 吉野正, 高田尚良
  • Organizer: 日本癌学会
  • Place of Presentation: 札幌
  • Year and Date: 20120919-22
• [Presentation] (2012)
  • Author(s): Okada Hiroyuki,Takata Katuyoshi,Kawahara Yoshihiro,Nasu Junichiro,Kawano Seiji,Kita Masahide,TuzukiTakao,Matubara Minoru,Hori Keisuke,Kanzaki Hiromitu,Kobayashi Sayo, Yoshino Tadashi, Yamamoto Kazuhide
  • Organizer: 米国消化器病週間(DDW)
  • Place of Presentation: アメリカ
  • Year and Date: 20120519-22
• [Presentation] 十二指腸濾胞性リンパ腫の発症機構とエビジェネティクス解析 (2012)
  • Author(s): 高田尚良, 岡剛史, 安藤翠, 都地友紘, 佐藤康晴, 中村直哉, 吉野正
  • Organizer: 日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 20120426-28
• [Presentation] Nodal follicular lymphoma with incomplete follicular dendritic cell networks (2012)
  • Author(s): 崔巍, 佐藤康晴, 高田尚良, 黄新剛, 大野京太郎, 吉野正
  • Organizer: 日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 20120426-28
• [Presentation] Upregulation of Ezh2 expression Correlates with Higher Tumor Proliferation and Grade in Non Hodgkin B and T Cell Lymphoma American Association of Cancer Research (AACR) (2012)
  • Author(s): Abd Al-Kader Lamia, Oka Takashi, Takata Katsuyoshi, Sun Xu, Sato Hiaki, Murakami Ichiro, Kimura Hiroshi Yoshino Tadashi
  • Organizer: Annual Meeting
  • Place of Presentation: アメリカ
  • Year and Date: 20120331-0404
• [Presentation] Identification and profiling of aberrantly expressed microRNAs during progression of adult T-cell leukemia/lymphoma (ATLL) (2012)
  • Author(s): Oka Takashi, Kitamura Yuta, Tamura Maiko, Sato Hiaki, Washio Kana, Abd Al-Kader Lamia, Ouchida Mamoru, Utsunomiya Atae, Yoshino Tadashi
  • Organizer: The 5th International Symposium for Future Technology Creating Better Human Health and Society Comprehensive Approach to Cancer and Infectious Diseases
  • Year and Date: 20120315-16