2013 Fiscal Year Final Research Report
Different mechanism of carcinogenesis and development in intrahepatic cholangiocarcinoma according to the level of bile ducts
| Project/Area Number |
23590399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
AISHIMA Shinichi 九州大学, 医学(系)研究科(研究院), 准教授 (70346774)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胆管癌 / 発がん / 酸化ストレス / 糖代謝 / 浸潤 / 増殖 |
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| Research Abstract |
Intrahepatic cholangiocarcinomas (ICCs) consist of heterogenous carcinoma arising from different anatomical sites of the liver. This heterogeneity depends on that the origin of ICCs is different level of biliary tree based on the gross and histologic examination. We examined oxidative stress marker related with carcinogenesis, Slit-ROBO1 signal pathway, and glucose metabolism in carcinogenesis and progression of ICCs, exept we did not perform the investigation of bile acid and its receptor in ICC. As a results, 1) cyclooxygenase-2 (COX2) expression is associated with VEGF-C expression and presence of lymph node metastasis, 2) decreased expression of ROBO1 by SiRNA in RBE cells is associated with proliferation and migration, and pomote lymph node metastasis, and 3) Glucose transporter-1 (GLUT1) expression is related with aggressive phenotype of ICCs.
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[Journal Article] Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma2013
Author(s)
Mano Y, Aishima S, Fukuhara T, Tanaka Y, Kubo Y, Motomura T, Toshima T, Iguchi T, Shirabe K, Maehara Y, Oda Y.
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Journal Title
Hum Pathol
Volume: 44
Pages: 2419-26
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