2013 Fiscal Year Final Research Report

Effects of MMP-9 on plaque rupture: development of a novel model for acute coronary syndromes.

Research Project

Project/Area Number	23590401
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Human pathology
Research Institution	Saga University
Principal Investigator	WATANABE Teruo 佐賀大学, 総合分析実験センター, 客員研究員 (40037396)
Co-Investigator(Kenkyū-buntansha)	FAN Jianglin 山梨大学, 医学工学総合研究部, 教授 (60272192) KITAJIMA Shuji 佐賀大学, 総合分析実験センター, 准教授 (70284643) NISHIJIMA Kazutoshi 佐賀大学, 総合分析実験センター, 助教 (70435874)
Project Period (FY)	2011 – 2013
Keywords	MMP-9 / 動脈硬化 / 遺伝子組換え / ウサギ / 病態モデル
Research Abstract	Matrix metalloprotease (MMP)-9 transgenic (Tg) rabbits were analyzed to clarify the effects of MMP-9 on atherosclerosis. With high cholesterol diet loading, the arteriosclerotic lesion in MMP-9 Tg rabbit was larger than in control rabbit. Subsequently, MMP-9 Tg rabbit was mated with MMP-12 (known to accelerate the initiation of atherosclerosis) Tg rabbit and MMP-9/12 Tg rabbit was established as a candidate for a novel model for acute coronary syndromes.