2013 Fiscal Year Final Research Report
The role of Mastermind in B-cell lymphoma
| Project/Area Number |
23590413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMARU Jun-ichi 埼玉医科大学, 医学部, 教授 (30188429)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血液 / B細胞性リンパ腫 / Mastermind / Notch |
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| Research Abstract |
Mastermind (Mam) is a pivotal modulator of Notch signaling and has essential roles in the differentiation of B-cells from GC to MZ. We showed that 1) MamL1 and MamL3 were expressed in the GC and MZ of reactive lymph node. 2) Mam was expressed in 50% of cases with MC subtype of the Hodgkin lymphoma, whereas the expression was low in the cases with NS subtype. 3) Mam was expressed in the cases with follicular lymphoma and was low in the cases with marginal zone lymphoma. 4) The expression of Hes-1 was correlated with the expression of Notch1 or Jag2 in lymphoma cell lines, suggesting the Notch pathway is activated by cell-autonomously within lymphoma cell lines. 5) The expression of Hes-1 was correlated with LR11 expression. LR11 may be activated in parallel with Notch activation. Further investigation of the expression of Notch related molecules and the status of Notch activation is needed to clarify the biological and pathological differences in B-cell lymphomas originated from the GC.
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[Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma2014
Author(s)
Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C
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Journal Title
Leuk Lymphoma
Volume: (印刷中)
DOI
Peer Reviewed
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[Journal Article] G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow2014
Author(s)
Shimizu N, Nakaseko C, Jiang M, Nishii K, Yokote K, Iseki T, Higashi M, Tamaru J, Schneider WJ, Bujo H
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Journal Title
Ann Hematol
Volume: (印刷中)
DOI
Peer Reviewed
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[Journal Article] LR11: a novel biomarker identified in follicular lymphoma2013
Author(s)
Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Meizi Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C
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Journal Title
British Journal of Haematology
Volume: (印刷中)
DOI
Peer Reviewed
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[Journal Article] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas2011
Author(s)
Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, et. al
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Journal Title
Am J Surg Pathol
Volume: 35(12)
Pages: 1812-7
Peer Reviewed
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[Presentation] LR11: implications for molecular targeting therapy in lymphoma2013
Author(s)
Morihiro Higashi, Michihide Tokuhira, Takeharu Kawaguchi, Masahiro Takeuchi, Chikako Ohwada, Chiaki Nakaseko, Toshiki Watanabe, Hideaki Bujo, Masahiro Kizaki, Jun-ichi Tmaru
Organizer
2nd Joint Scientific Meeting Medical University of Vienna and Chiba University
Place of Presentation
ウィーン,オーストリア
Year and Date
2013-02-15
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