2013 Fiscal Year Final Research Report
Regulatory mechanism for cancer stem cells in various tumors
| Project/Area Number |
23590425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Osaka University |
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Principal Investigator |
EIICHI Morii 大阪大学, 医学(系)研究科(研究院), 教授 (10283772)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腫瘍幹細胞 / 制御因子 / 腫瘍 |
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| Research Abstract |
Cancer stem cells (CSCs) are supposed to cause metastasis and recurrence of tumors, because these are restant to various therapies. Here, we analyzed CSCs in various tumors. In Hodgkin lymphoma, small cells with single nucleus were CSCs, which expeled efficiently reactive oxygen species (ROS). In lymphoplasmacytic lymphoma, tumor cells with no expression of B lymphocyte and plasma cell markers were CSCs, because these non-expressing cells yielded B lymphocyte marker-positive and plasma cell marker-positive cells. These non-expressing cells were resistant to anti-cancer drugs and eliminated ROS. Moreover, in endometrioid adenocarcinoma, aldehyde dehydrogenase (ALDH) high cells, which were revealed to be CSCs, were regulated by TGF-beta signal. The inhibition of signal increased ALDH-hi population, and the addition of TGF-beta stimulator reduced ALDH-hi. These results suggested that CSCs were present in various tumors, and their regulation will be necessary for anti-tumor therapies.
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[Journal Article] Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages2013
Author(s)
Satoh S, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O,Akira S
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Journal Title
Nature
Volume: 495
Pages: 524-528
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[Journal Article] Tumor-associated macrophages in diffuse large B-cell lymphoma : a study of the Osaka Lymphoma Study Group2012
Author(s)
Wada N, Zaki MA, Hori Y, Hashimoto K, Tsukaguchi M, Tatsumi Y, Ishikawa J, Tominaga N, Sakoda H, Take H, Tsudo M, Kuwayama M, Morii E, Aozasa K
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Journal Title
Histopathology
Volume: 60
Pages: 313-319
Peer Reviewed
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[Journal Article] Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favorable prognosis : a study of the Osaka Lymphoma Study Group2012
Author(s)
Wada N, Zaki MA, Kohara M, Ogawa H, Sugiyama H, Nomura S, Matsumura I, Hino M, Kanakura Y, Inagaki H, Morii E, Aozasa K
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Journal Title
Histopathology
Volume: 60
Pages: 924-932
Peer Reviewed
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[Journal Article] Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications2011
Author(s)
Rahadiani N, Ikeda JI, Mamat S, Matsuzaki S, Ueda Y, Umehara R, Tian T, Wang Y, Enomoto T, Kimura T, Aozasa K, Morii E
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Journal Title
Cancer Sci
Volume: 102
Pages: 903-908
Peer Reviewed
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[Journal Article] Presence of B-cell clones in T-cell lymphoma2011
Author(s)
Zaki MA, Wada N, Kohara M, Ikeda JI, Hori Y, Fujita S, Ogawa H, Sugiyama H, Hino M, Kanakura Y, Morii E, Aozasa K
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Journal Title
Eur J Haematol
Volume: 86
Pages: 412-419
Peer Reviewed
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[Journal Article] Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma2011
Author(s)
Zaki MA, Wada N, Ikeda JI, Shibayama H, Hashimoto K, Yamagami T, Tatsumi Y, Tsukaguchi M, Take H, Tsudo M, Morii E, Aozasa K
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Journal Title
Virchows Arch
Volume: 459
Pages: 361-366
Peer Reviewed
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