2013 Fiscal Year Final Research Report
Comprehensive molecular and pathological analysis of Mesothelin expression
| Project/Area Number |
23590435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAJINO Kazunori 順天堂大学, 医学部, 助教 (80260066)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 中皮腫 / ERC/Mesothelin |
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| Research Abstract |
Mesothelioma, caused by the exposure to asbestos, is a malignant tumor with poor prognosis. ERC/Mesothelin (ERC) is a tumor maker useful for the diagnosis of mesothelioma and the evaluation of its prognosis. In this study, we showed that the expression of ERC is regulated by microRNA. To establish the novel treatment for mesothelioma, we immunized mice with cultured cells derived from human mesothelioma, and isolated the monoclonal antibodies having the anti-proliferative activity for the mesothelioma cells.
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[Journal Article] Todo S. C-ERC/ mesothelin provokes lymphatic invasion of colorectal adenocarcinoma2014
Author(s)
Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A
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Journal Title
J Gastroenterol
Volume: 49
Pages: 81-92
Peer Reviewed
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