2013 Fiscal Year Final Research Report
Inhibition of angiogenesis by internalization inducer
| Project/Area Number |
23590459
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Osaka University |
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Principal Investigator |
NARAZAKI Masashi 大阪大学, 医学(系)研究科(研究院), 助教 (00467573)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血管新生 / Neuropilin-1 / 血管内皮細胞 / 受容体 |
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| Research Abstract |
We analyzed the inhibitory mechanisms of angiogenesis by using three groups of molecule, including artificial compounds, physiological cytokine, and inhibitory antibody. Neuropilin-1 is a cell surface receptor of VEGF. We showed that sulfate polysaccharide, fucoidan, and oligo-guanosine nucleotide could internalize Neuropilin-1 from the endothelial cell surface to lysosome as an "internalization-inducer". Moreover, we showed that fucoidan and oligo-guanosine nucleotide could inhibit angiogenesis in vivo. We analyzed the interaction of a cytokine VEGF-B with FGF receptor. We proposed the possibility that VEGF-B works as an antagonist of FGF receptor. And we analyzed the biochemical property of the antibody against the members of Ephrin family that are recently identified to have a role in angiogenesis.
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