• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

A therapy to eradicate osteoporosis

Research Project

  • PDF
Project/Area Number 23590460
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionTottori University

Principal Investigator

HAYASHI Shin-Ichi  鳥取大学, 医学部, 教授 (50208617)

Project Period (FY) 2011 – 2013
Keywords免疫学 / 骨吸収 / 炎症 / 病理学 / 再生医学
Research Abstract

In this study, to develop the novel therapy for osteoporosis, regulatory cells for osteoclastogenesis were characterized. A removal of regulatory cells in peritoneal cavity resulted in the reduction of the osteoclatogenesis from bone marrow cells for more than 1 year. A removal of T lineage cells expressing CD4, CD8a, or CD5, but not B220, CD11b, CD11c, NK1.1, or IL7Ra in the bone marrow also reduced the osteoclastogenesis of bone marrow cells. These observations were confirmed by using mutant mice lacking T cells or T and B cells. Moreover, mice carrying T cell antigen receptor-transgene but not Btk mutation were affected a hypotonic treatment in the peritoneal cavity. Taken together, the osteoclastogenesis is suggested to be regulated by two-related systems presented in extra-medullary and intra-medullary sites.

  • Research Products

    (22 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Dual system for the transport of self-antigens from the skin2013

    • Author(s)
      Yoshino, M., Murata, A., Shimoda, Y., Hikosaka, M., and Hayashi, S.I.
    • Journal Title

      Curr. Res. in Immunology

      Volume: 7 Pages: 1-12

  • [Journal Article] Origins and properties of dental, thymic, and bone marrow mesenchymal cells and their stem cells2012

    • Author(s)
      Komada, Y. Yamane, T., Kadota, D., Isono, K., Takakura, N., Hayashi, S.I., and Yamazaki, H.
    • Journal Title

      PLoS One

      Volume: 7 Pages: e46436

    • DOI

      10.1371/journal.pone.0046436

    • Peer Reviewed
  • [Journal Article] Stochastic differentiation into an osteoclast lineage from cloned macrophage-like cells2012

    • Author(s)
      Hayashi, S.I., Murata, A., Okuyama, K., Shimoda, Y., Hikosaka, M., Yasuda, H., and Yoshino, M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 428 Pages: 303-308

    • DOI

      10.1016/j.bbrc.2012.10.052

    • Peer Reviewed
  • [Journal Article] CCR7-independent transport of skin antigens occurs in the dermis2012

    • Author(s)
      Yoshino, M., Okuyama, K., Murata, A., Tomura, M., and Hayashi, S.I.
    • Journal Title

      Eur. J. Immunol.

      Volume: 42 Pages: 1459-1467

    • DOI

      10.1002/eji.201142114

    • Peer Reviewed
  • [Journal Article] A checkpoint in B-lymphopoiesis related to Notch resistance2012

    • Author(s)
      Okuyama, K., Murata, A., Sudo, T., Yoshino, M., and Hayashi, S.I.
    • Journal Title

      Biochem Biophys. Res. Commun.

      Volume: 417 Pages: 141-146

    • DOI

      10.1016/j.bbrc.2011.11.072

    • Peer Reviewed
  • [Journal Article] HLA-A2-restricted glypican-3 peptide-specific CTL clones induced by peptide vaccine show high avidity and antigen-specific killing activity against tumor cells2011

    • Author(s)
      Yoshikawa, T., Nakatsugawa, M., Suzuki, S., Shirakawa, H., Nobuoka, D., Sakemura, N., Motomura, Y., Tanaka-Harada, Y., Hayashi, S.I., and Nakatsura, T.
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 918-925

    • DOI

      10.1111/j.1349-7006.2011.01896.x

    • Peer Reviewed
  • [Journal Article] Methods for investigation of osteoclastogenesis using mouse embryonic stem cells. In "Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases"Ed. N.I. zur Nieden2011

    • Author(s)
      Tsuneto, M., Yamane, T., and Hayashi, S.I.
    • Journal Title

      A Humana Press Book, Springer Science+Business Media

      Volume: Vol. 690 (Methods in Molecular Biology) Pages: 239-253

    • DOI

      10.1007/978-1-60761-962-8_16

  • [Presentation] Cell adhesion mediated by Notch ligands; an implication for mast cell accumulation in chronic inflammation2013

    • Author(s)
      Murata, A., Yoshino, M., Shimoda, Y., Hikosaka, M., Yagita, H., and Hayashi, S.I.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉(3-J-W56-12-P)
    • Year and Date
      2013-12-13
  • [Presentation] Up-regulation of Aicda gene expression in IgE producing hybridomas : a model of class switch recombination in plasma cells2013

    • Author(s)
      Hikosaka, M., Murata, A., Shimoda, Y., Yoshino, M., and Hayashi, S.I.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉(2-H-W38-10-P)
    • Year and Date
      2013-12-12
  • [Presentation] Analysis of cells transporting skin self-antigens to regional lymph nodes under CCR7-deficient conditions2013

    • Author(s)
      Yoshino, M., Murata, A., Shimoda, Y., Hikosaka, M., and Hayashi, S.I.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉(2-I-W39-19-P)
    • Year and Date
      2013-12-12
  • [Presentation] Presence of CCR7-independent transport of skin antigens from the dermis2012

    • Author(s)
      Yoshino, M., Okuyama, K., Murata, A., Tomura, M., Shimoda, Y., Hikosaka, M., and Hayashi, S.I.
    • Organizer
      European Congress of Immunology
    • Place of Presentation
      Glasgow, Scotland
    • Year and Date
      20120905-08
  • [Presentation] CCR7-independent transport of skin antigens occurs in the dermis2012

    • Author(s)
      Yoshino, M., Okuyama, K., Murata, A., Tomura, M., Shimoda, Y., Hikosaka, M., and Hayashi, S.I.
    • Organizer
      The 20th International Symposium on Molecular Cell Biology of Macrophages 2012
    • Place of Presentation
      東京
    • Year and Date
      20120615-16
  • [Presentation] Notch ligands differentially regulate the adhesion of immune cells2012

    • Author(s)
      Murata, A., Yoshino, M., Shimoda, Y., Hikosaka, M., Okuyama, K., Yagita, H., and Hayashi, S.I.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸(2-D-W28-7-O/P)
    • Year and Date
      2012-12-06
  • [Presentation] Role of CCR7-independent transport of skin self-antigens on skin immunity2012

    • Author(s)
      Yoshino, M., Okuyama, K., Murata, A., Tomura, M., Shimoda, Y., Hikosaka, M., and Hayashi, S.I.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸(1-L-W21-3-O/P)
    • Year and Date
      2012-12-05
  • [Presentation] Function of Notch ligands as adhesion molecules2011

    • Author(s)
      Murata, A., Okuyama, K., Egawa, Y., Sawada, A., Shimoda, Y., Yoshino, M., and Hayashi, S.I.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川(4T11pII-2 (3P-0549))
    • Year and Date
      20111215-16
  • [Presentation] Presence of CCR7-independent transport of skin antigens from the dermis2011

    • Author(s)
      Yoshino, M., Okuyama, K., Murata, A., Egawa, Y., Sawada, A., Shimoda, Y., Hayashi, S.I.
    • Organizer
      76th Japanese Society of Interferon & Cytokine Research-19th International Symposium on Molecular Cell Biology of Macrophages 2011 Joint meeting
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20110525-27
  • [Presentation] Characterization of CD16- NK cell precursors in the bone marrow2011

    • Author(s)
      Egawa, Y., Okuyama, K., Murata, A., Sawada, A., Shimoda, Y., Yoshino, M., and Hayashi, S.I.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉(3-G-W58-3-O/P)
    • Year and Date
      2011-11-29
  • [Presentation] Differential regulation of cell adhesion by Notch ligands2011

    • Author(s)
      Murata, A., Okuyama, K., Egawa, Y., Sawada, A., Shimoda, Y., Sakano, S., Yagita, H., Yoshino, M., and Hayashi, S.I.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉(3-L-W68-15-P)
    • Year and Date
      2011-11-29
  • [Presentation] No tch抵抗性を示すB細胞分化段階/Notch resistant checkpoint during B-lymphopoiesis2011

    • Author(s)
      Okuyama, K., Murata, A., Egawa, Y., Sawada, A., Shimoda, Y., Yoshino, M., and Hayashi, S.I.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉(2-G-W37-9-P)
    • Year and Date
      2011-11-28
  • [Presentation] Description of T cell receptor selection events with an in vitro culturing approach2011

    • Author(s)
      Sawada, A., Okuyama, K., Murata, A., Egawa, Y., Shimoda, Y., Yoshino, M., and Hayashi, S.I.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉(1-L-W22-6-O/P)
    • Year and Date
      2011-11-27
  • [Presentation] CCR7非依存的に皮膚自己抗原を輸送する担当細胞の探索/Analysis of cells transporting skin self-antigens to regional lymph nodes in a CCR7-independent manner2011

    • Author(s)
      Yoshino, M., Okuyama, K., Murata, A., Egawa, Y., Sawada, A., Shimoda, Y., and Hayashi, S.I.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉(1-C-W4-11-P)
    • Year and Date
      2011-11-27
  • [Remarks]

    • URL

      http://www.med.tottori-u.ac.jp/immunol/5983.html

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi