Analysis of gliomagenesis using novel mouse glioma model

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590465
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kyushu University
• Principal Investigator: MARUMOTO Tomotoshi 九州大学, 生体防御医学研究所, 准教授 (60363511)
• Co-Investigator(Kenkyū-buntansha): TANI Kenzaburo 九州大学, 生体防御医学研究所, 教授 (00183864)
• Project Period (FY): 2011 – 2013
• Keywords: 脳腫瘍 / 膠芽腫

Research Abstract

Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. However the cellular origin of this tumor has not been well understood. We showed that GBM can originate from differentiated cells in the central nervous system (CNS), including cortical neurons. Transduction by oncogenic lentiviral vectors of neural stem cells (NSCs), astrocytes, or even mature neurons in the brains of mice could give rise to GBM. These data will help understand the gliomagenesis and contribute to the development of the new strategy of treatment.

Research Products

• [Journal Article] Analysis of essential pathways for self-renewal in common marmoset embryonic stem cells (2014)
  • Author(s): Nii T, Marumoto T, Kawano H, Yamaguchi S, Liao J, Okada M, Sasaki E, Miura Y, Tani K
  • Journal Title: FEBS Open Bio Volume: 4(equal contribution) Pages: 213-9
• [Journal Article] Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells (2013)
  • Author(s): Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamato S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y, Tani K
  • Journal Title: Mol Ther. Volume: 6(equal contribution) Pages: 1242-50
• [Journal Article] Dedifferentiation of neurons and astrocytes by oncogenes can induce glioblastomas (2012)
  • Author(s): Friedmann-Morvinski D, Bushong E, Ke E, Soda Y, Marumoto T, Singer O, Ellisman M and Verma IM
  • Journal Title: Science Volume: 338 Pages: 1080-4
• [Journal Article] MiuraY,TaniK.Characterization of common marmoset dysgerminoma like tumor induced by thelentiviral expression of reprogramming factors
  • Author(s): Yamaguchi S, Marumoto T, Nii T, Kawano H, Liao J, Nagai Y, Okada M, Takahashi A,Inoue H, Sasaki E, Fujii H, Okano S, Ebise H, Sato T, Suyama M, Okano H,MiuraY,Tani K
  • Journal Title: Cancer Sci. Volume: (in press), (Epub ahead of print), (equal contribution)
  • DOI: 10.1111/cas.12367