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2013 Fiscal Year Final Research Report

Mechanism of endometrial cell survival in the formation of endometriotic lesion

Research Project

  • PDF
Project/Area Number 23590476
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

TAMURA Kazuhiro  東京薬科大学, 薬学部, 准教授 (70281409)

Project Period (FY) 2011 – 2013
Keywords子宮内膜症 / 炎症 / 動物モデル / アンチトリプシン
Research Abstract

Endometriosis is the intractable disorder characterized by the presence of endometrial tissue outside of the uterine cavity. Distinct endometriosis-like lesions in our experimental internal bleeding mouse model exhibited the expression of high levels of inflammation factors. To identify changes in protein levels in endometriosis-like lesions, protein profile changes were compared with control (no bleeding) mice. Cell lysates from lesions from uOVX and control mice were analyzed by 2-D gel electrophoresis, followed by MALDI-TOF MS. The level of alpha1-antitrypsin (a1-AT) is decreased in lesions from mice that underwent uOVX. In cultured stromal cells, a1-AT inhibited the expression of inflammation and cell survival factors. Reduced a1-AT levels may exacerbate local inflammation, suggesting the possible involvement of a1-AT in the pathophysiology of endometriosis.

  • Research Products

    (9 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Stathmin regulates hypoxia- inducible factor-1αexpression through the mammalian target of rapamycin pathway in ovarian clear cell adenocarcinoma2013

    • Author(s)
      Tamura K, Yoshie M, Miyajima E, Kano M, Tachikawa E
    • Journal Title

      ISRN Pharmacol.

      Pages: 279593

    • Peer Reviewed
  • [Journal Article] Protease-activated receptor-stimulated interleukin-6 expression in endometriosis-like lesions in an experimental mouse model of endometriosis2012

    • Author(s)
      Shinohara A, Kutsukake M, Takahashi M, Kyo S, Tachikawa E, Tamura K
    • Journal Title

      J Pharmacol Sci.

      Volume: 119 Pages: 40–51

    • Peer Reviewed
  • [Presentation] Inhibitory action ofα_1-anti-trypsin on proinflammatory cytokine expression in human endometrial stromal cells2014

    • Author(s)
      Tamura K, Fumoto K, Otsu M, Yoshie M, Kajihara T, Ishihara O, Isaka K, Tachikawa E
    • Organizer
      国際内分泌学会議・米国内分泌会議(ICE/ENDO2014)
    • Place of Presentation
      シカゴ
    • Year and Date
      20140600
  • [Presentation] ヒト子宮内膜間質細胞の機能に及ぼすα_1-アンチトリプシン発現抑制の効果2014

    • Author(s)
      乙津舞好、田村和広、吉江幹浩、桑原直子、立川英一
    • Organizer
      第72回西東京内分泌代謝研究会
    • Place of Presentation
      東京
    • Year and Date
      20140600
  • [Presentation] 卵巣摘出ヌードマウスに移植した子宮内膜細胞の挙動2013

    • Author(s)
      麓惠子,田村和広,高島陽香,吉江幹浩,草間和哉,沓掛真彦,立川英一
    • Organizer
      第106回繁殖生物学会大会
    • Place of Presentation
      東京
    • Year and Date
      20130900
  • [Presentation] ヒト子宮内膜細胞のヌードマウスへの移植で形成される内膜症様病変におけるα_1‐アンチトリプシン(AAT)レベルの低下とAATの機能2013

    • Author(s)
      田村和広,高島陽香,麓恵子,沓掛真彦,吉江幹浩,立川英一,梶原健,内野聡美,石原理
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台
    • Year and Date
      20130400
  • [Presentation] ヒト子宮内膜細胞における炎症性サイトカイン発現に及ぼすα1-アンチトリプシンの作用2013

    • Author(s)
      麓惠子,田村和広,高島陽香,沓掛真彦,吉江幹浩,立川英一,井坂惠一
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      20130300
  • [Presentation] プロテアーゼ活性化受容体刺激下のヒト子宮内膜間質細胞の炎症因子とmTORシグナルに及ぼすα1-アンチトリプシンの作用2012

    • Author(s)
      高島陽香,田村和広,麓惠子,沓掛真彦,吉江幹浩,立川英一,井坂惠一
    • Organizer
      第70回西東京内分泌代謝研究会
    • Place of Presentation
      東京
    • Year and Date
      20121200
  • [Remarks]

    • URL

      http://www.ps.toyaku.ac.jp/wp/shinkeiyakuri/

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Published: 2015-07-16  

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