2013 Fiscal Year Final Research Report
Development of a novel therapeutic for AIDS using humanized mouse model and improvement of HAART
| Project/Area Number |
23590481
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
OKUMA Kazu 国立感染症研究所, 血液・安全性研究部, 室長 (80315085)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Yuetsu 琉球大学, 免疫学講座, 教授 (30163588)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヒト免疫不全ウイルス１型 / エイズ / 新規治療薬 / ヒト化マウス / 感染実験動物モデル |
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| Research Abstract |
In order to improve the standard therapy for AIDS/human immunodeficiency virus (HIV) infection, HAART, recombinant vesicular stomatitis viruses (rVSVs) expressing HIV-1 receptors and/or OX40L were generated as candidates for novel drugs. In vitro and in immunodeficient mice transplanted with hematopoietic stem cells from human cord blood (humanized mice) and then infected by HIV-1, the rVSVs could inhibit HIV-1 infection, indicating that they have a therapeutic potential for AIDS/HIV-1 infection.
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Research Products
(4 results)
