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2013 Fiscal Year Final Research Report

Mechanisms of suppressed recall responses of CD8+T cells during malaria infection

Research Project

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Project/Area Number 23590487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionNagasaki University

Principal Investigator

MIYAKODA Mana  長崎大学, 医歯(薬)学総合研究科, 講師 (30398151)

Project Period (FY) 2011 – 2013
Keywordsマラリア / CD8+T細胞 / 二次応答
Research Abstract

FTY720, which inhibits lymphocyte emigration from lymphoid organs, did not affect against the reduced expansion of memory OT-I cells compared with naive OT-I cells during OVA malaria infection, suggesting that the recall response was reduced systemically during malaria infection.
Immunohistochemistory indicated that OT-I cells and macrophages did not accumulate in white pulp of spleen so much during OVA malaria infection. This result suggested that the location of antigen presentation may be important for cell expansion.
Immunization of OVA-pulsed BMDC did not induced the difference in the ratio of naive OT-I cells and memory OT-I cells during the infections between wild type malaria and listeria, implying the possibility that the reduced recall response might be dependent on antigen presentation.

  • Research Products

    (15 results)

All 2014 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (5 results) Book (2 results)

  • [Journal Article] IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major2014

    • Author(s)
      Akbari M, Honma K, Kimura D, Miyakoda M, Kimura K, Matsuyama T, Yui K
    • Journal Title

      J Immunol

      Volume: 192巻 Pages: 2271-9

    • Peer Reviewed
  • [Journal Article] Secure splenic delivery of plasmid DNA and its application to DNA vaccine2013

    • Author(s)
      Kurosaki T, Kodama Y, Muro T, Higuchi N, Nakamura T, Kitahara T, Miyakoda M, Yui K, Sasaki H
    • Journal Title

      Biol Pharm Bull

      Volume: 36巻 Pages: 1800-6

    • Peer Reviewed
  • [Journal Article] CD8+ T cells specific for a malaria cytoplasmic antigen form clusters around infected hepatocytes and are protective at the liver stage of infection2013

    • Author(s)
      Kimura K, Kimura D, Matsushima Y, Miyakoda M, Honma K, Yuda M, Yui K
    • Journal Title

      Infect Immun

      Volume: 81巻 Pages: 3825-34

    • Peer Reviewed
  • [Journal Article] Accumulation of major histocompatibility complex class II(+)CD11c(-) non-lymphoid cells in the spleen during infection with Plasmodium yoelii is lymphocyte-dependent2013

    • Author(s)
      Kamei R, Miyakoda M, Tamura T, Kimura D, Honma K, Kimura K, Yui K
    • Journal Title

      Microbiol Immunol

      Volume: 57巻 Pages: 213-23

    • Peer Reviewed
  • [Journal Article] Development of memory CD8+ T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA2012

    • Author(s)
      Miyakoda M, Kimura D, Honma K, Kimura K, Yuda M, Yui K
    • Journal Title

      J Immunol

      Volume: 189巻 Pages: 4396-404

    • Peer Reviewed
  • [Journal Article] The species specificity of immunity generated by live whole organism immunisation with erythrocytic and pre-erythrocytic stages of rodent malaria parasites and implications for vaccine development2012

    • Author(s)
      Inoue M, Tang J, Miyakoda M, Kaneko O, Yui K, Culleton R
    • Journal Title

      Int J Parasitol

      Volume: 42巻 Pages: 859-70

    • Peer Reviewed
  • [Journal Article] マラリア感染と免疫記憶からワクチン開発へ2011

    • Author(s)
      由井克之,木村大輔,都田真奈
    • Journal Title

      実験医学

      Volume: 29巻 Pages: 171-5

  • [Journal Article] Characterization of waves of leukocyte recruitment to the lung allograft and the effect of CTLA4-Ig2011

    • Author(s)
      Taguchi T, Inamura Y, Honma K, Kimura D, Miyakoda M, Miyazaki T, Tsuchiya T, Yamasaki N, Tagawa T, Nagayasu T and Yui K
    • Journal Title

      Acta Medica Nagasakiensia

      Volume: 56巻 Pages: 27-34

    • Peer Reviewed
  • [Presentation] IRF4 is critical for proliferation and effector differentiation of CD8+T cells2013

    • Author(s)
      都田真奈
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2013-12-12
  • [Presentation] マラリア原虫感染における抗原特異的CD8+T細胞の二次応答抑制2013

    • Author(s)
      都田真奈
    • Organizer
      第82回日本寄生虫学会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-31
  • [Presentation] Development of memory CD8^+ T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA2012

    • Author(s)
      Miyakoda M
    • Organizer
      キーストンシンポジウム
    • Place of Presentation
      バンフ(カナダ)
    • Year and Date
      2012-12-15
  • [Presentation] IRF4 controls cytokine signals and plays critical roles for proliferation and differentiation of CD8^+ T cells2012

    • Author(s)
      Miyakoda M
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-07
  • [Presentation] マラリア原虫感染中にみられる抗原特異的記憶CD8+T細胞の二次応答の抑制2012

    • Author(s)
      都田真奈
    • Organizer
      第81回寄生虫学会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-03-24
  • [Book] 寄生虫学研究|材料と方法2012

    • Author(s)
      木村大輔,本間季里,都田真奈,由井克之
    • Total Pages
      51-4
    • Publisher
      三恵社
  • [Book] 寄生虫学研究|材料と方法2012

    • Author(s)
      本間季里,木村大輔,都田真奈,由井克之
    • Total Pages
      81-84
    • Publisher
      三恵社

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Published: 2015-07-16  

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