2013 Fiscal Year Final Research Report
Th2 independent NB expulsion by natural helper cells
| Project/Area Number |
23590488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
HONMA Kiri 長崎大学, 医歯(薬)学総合研究科, 准教授 (70307940)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Th2 / 自然リンパ球 / 蠕虫 / 腸管免疫 / サイトカイン |
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| Research Abstract |
Interferon regulatory factor 4 (IRF4) is the development of Th2. In IRF4-deficient mice (IRF4 KO), Th2 development does not occur. Nippostrongyrus brasiliensis (NB) is one of parasite and is eliminated by antigen-specific Th2, which is generated during infection. However, Th2 independent NB elimination was found in IRF4 KO. This study indicated that group2 innate lymphocytes (ILC2) played the crucial role in Th2 independent NB expulsion and IRF4 directly regulated the Th2 cytokine production, such as IL5 or IL13 although IRF4 was dispensable of ILC2 development.
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[Journal Article] Smad2/3 and IRF4 Play a Cooperative Role in IL-9–Producing T Cell Induction2013
Author(s)
Taiga Tamiya, Kenji Ichiyama, Hitoshi Kotani, Tomohiro Fukaya, Takashi Sekiya, Takashi Shichita, Kiri Honma, Katsuyuki Yui, Toshifumi Matsuyama, Takako Nakao, Satoru Fukuyama, Hiromasa Inoue, Masatoshi Nomura, Akihiko Yoshimura
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Journal Title
J. Immunol.
Volume: 191
Pages: 2360-2371
Peer Reviewed
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[Journal Article] Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel2011
Author(s)
Shindo H., Yasui K., Yamamoto K., Honma K., Yui K., Kohno T., Yuhua Ma Y., Jiew CK., Kubo Y., Aihara H., Ito T., Nagayasu T., Matsuyama T., Hayashi H.
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Journal Title
Cytokine
Volume: 56
Pages: 564-572
Peer Reviewed
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