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2013 Fiscal Year Final Research Report

Aberrant differentiation of dendritic cells in malaria infection associated with decreased expression of IRF4/IRF8

Research Project

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Project/Area Number 23590492
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionYokohama City University

Principal Investigator

ICHINO Motohide  横浜市立大学, 医学部, 助教 (60271368)

Co-Investigator(Renkei-kenkyūsha) TAMURA Tomohiko  横浜市立大学, 医学研究科, 教授 (50285144)
NISHIYAMA Akira  横浜市立大学, 医学研究科, 准教授 (80589664)
HOTTA Chie  横浜市立大学, 医学部, 助教 (80363810)
Project Period (FY) 2011 – 2013
Keywords樹状細胞 / マラリア / 転写因子
Research Abstract

It has been reported that malaria parasite infection suppresses host immune system by interfering with the maturation of dendritic cells (DCs) playing a pivotal role in immune responses. However the molecular mechanisms are not well understood. The present study shows that malaria parasite-infected erythrocytes can interact with host bone-marrow cells and cause aberrant differentiation of DCs by suppressing the transcriptional expression of transcription factors IRF4 and IRF8, by using a mouse model of malaria parasite infection.

  • Research Products

    (21 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (14 results) Remarks (2 results)

  • [Journal Article] The transcription factor IRF8 counteracts BCR ABL to rescue dendritic cell development in chronic myeloid leukemia2013

    • Author(s)
      Watanabe T, Hotta C, Koizumi S, Miyashita K, Nakabayashi J, Kurotaki K, Sato R G, Yamamoto M, Nakazawa M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Ikezawa Z, Aihara M, Ishigatsubo Y, Tamura T
    • Journal Title

      Cancer Res

      Volume: 73 (22) Pages: 6642-6653

    • Peer Reviewed
  • [Journal Article] Essential role of the IRF8 KLF4 transcription factor cascade in murine monocyte differentiation2013

    • Author(s)
      Kurotaki D, Osato N, Nishiyama A, Yamamoto M, Ban T, Sato H, Nakabayashi J, Umehara M, Miyake N, Matsumoto N, Nakazawa M, Ozato K, Tamura T
    • Journal Title

      Blood

      Volume: 121 (10) Pages: 1839 1849

    • Peer Reviewed
  • [Journal Article] Introduce My Article"Essential role of the IRF8 KLF4 transcription factor cascade in murine monocyte differentiation2013

    • Author(s)
      黒滝大翼,田村智彦
    • Journal Title

      臨床血液

      Volume: 54 (8) Pages: 786

  • [Journal Article] IRF8 KLF4転写因子カスケードによる単球分化制御2013

    • Author(s)
      黒滝大翼,田村智彦
    • Journal Title

      実験医学

      Volume: 31 (18) Pages: 2971 2975

  • [Journal Article] Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development2011

    • Author(s)
      Yamamoto M, Kato T, Hotta C, Nishiyama A, Kurotaki D, Yoshinari M, Takami M, Ichino M, Nakazawa M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamura T
    • Journal Title

      PLoS One

      Volume: 6 Pages: e25812

    • Peer Reviewed
  • [Presentation] IRF8 Inhibits the Activity of C/EBPαto Restrain Monocyte Dendritic Cell Progenitors from Differentiating into Neutrophils2013

    • Author(s)
      Yamamoto M, Kurotaki D, Nishiyama A, Uno K, Ichino M, Nakazawa M, Ozato K, Tamura T
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉(口頭発表)
    • Year and Date
      2013-12-13
  • [Presentation] IRF8 inhibits the activity of C/EBPαto restrain the neutrophil differentiation program in monocyte dendritic cell progenitors2013

    • Author(s)
      Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ichino M, Sasaki H, Ban T, Yoshinari M, Nakazawa M, Ozato K, Tamura T
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸(ポスター発表)
    • Year and Date
      2013-12-05
  • [Presentation] IRF8 inhibits the activity of C/EBPs to restrain neutrophil development in monocyte DC progenitors2013

    • Author(s)
      Kurotaki D, Yamamoto M, Uno K, Nishiyama A, Nakabayashi J, Morse HC 3rd, Ozato K, Tamura T
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌(口頭発表)
    • Year and Date
      2013-10-12
  • [Presentation] The IRF8 KLF4 transcription factor cascade is essential for the development of monocytes2013

    • Author(s)
      Kurotaki D, Osato N, Nishiyama A, Yamamoto M, Ban T, Sato H, Nakabayashi J, Umehara M, Nakazawa M, Miyake N, Matsumoto N, Ozato K, Tamura T
    • Organizer
      2013 Inaugural Meeting of the International Cytokine and Interferon Society
    • Place of Presentation
      San Francisco(ポスター発表)
    • Year and Date
      2013-10-02
  • [Presentation] 転写因子IRF8は単球樹状細胞前駆細胞においてC/EBPαの機能を阻害し、好中球分化能の喪失をもたらす2013

    • Author(s)
      黒滝大翼,山本道雄,宇野和宏,西山晃,中林潤,中津正年,Herbert C. Morse III,Keiko Ozato,田村智彦
    • Organizer
      第24回日本生体防御学会学術総会
    • Place of Presentation
      熊本(口頭発表)
    • Year and Date
      2013-07-12
  • [Presentation] The IRF8 KLF4 transcription factor cascade critically regulates the development of inflammatory monocytes2013

    • Author(s)
      Kurotaki D, Osato N, Nishiyama A, Yamamoto M, Ban T, Sato H, Nakabayashi J, Umehara M, Nakazawa M, Miyake N, Matsumoto N, Ozato K, Tamura T
    • Organizer
      The Joint International Meeting of the Japanese Society for Interferon and Cytokine Research and Macrophage Molecular and Cellular Biology 2013
    • Place of Presentation
      東京(ポスター発表)
    • Year and Date
      2013-05-20
  • [Presentation] ゲノム規模解析による単球分化に重要なIRF8 KLF4転写因子カスケードの発見2012

    • Author(s)
      黒滝大翼,大里直樹,西山晃,山本道雄,佐藤英明,中林潤,藩龍馬,梅原莱里奈,三宅紀子,松本直通,中沢正年,Keiko Ozato,田村智彦
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡(口頭発表)
    • Year and Date
      2012-12-14
  • [Presentation] Genome wide analyses revealed the IRF8 KLF4 transcription factor cascade during monocyte differentiation2012

    • Author(s)
      Kurotaki D, Osato N, Nishiyama A, Yamamoto M, Sato H, Nakabayashi J, Ban T, Ozato K, Tamura T
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸(口頭発表)
    • Year and Date
      2012-12-07
  • [Presentation] Impaired dendritic cell development in chronic myelogenous leukemia can be rescued by restoring expression of the transcription factor IRF82012

    • Author(s)
      Watanabe T, Hotta C, Kurotaki D, Sato RG, Yamamoto M, Nishiyama A, Tamura T
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸(口頭発表)
    • Year and Date
      2012-12-07
  • [Presentation] The transcription factor IRF8 rescues the dendritic cell development impaired by p210 Bcr/Abl2011

    • Author(s)
      Watanabe T, Hotta C, Sato GR, Yamamoto M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Aihara M, Ishigatsubo Y, Tamura T
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜(口頭発表)
    • Year and Date
      2011-12-14
  • [Presentation] Regulation of the development of monocyte subsets by interferon regulatory factor 82011

    • Author(s)
      Kurotaki D, Ichino M, Nishiyama A, Sato G, Yamamoto M, Ozato K, Tamura T
    • Organizer
      第40回日本免疫学会学術総会ワークショップ
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-28
  • [Presentation] ミエロイド細胞の分化・機能制御におけるIRF4, IRF8の役割2011

    • Author(s)
      山本道雄,加藤隆幸,堀田千絵,西山晃,黒滝大翼,吉成正裕,高見正道,市野素英,中津正年,松山俊文,上保竜太郎,北川誠一,Keiko Ozato,田村智彦
    • Organizer
      第13回神奈川血液・免疫フォーラム
    • Place of Presentation
      相模原(口頭発表)
    • Year and Date
      2011-11-11
  • [Presentation] Selective regulation of monocyte subsets by the transcription factor Interferon Regulatory Factor 82011

    • Author(s)
      Kurotaki D, Ichino M, Nishiyama A, Sato G, Yamamoto M, Ozato K, Tamura T
    • Organizer
      9th Joint Meeting of the International Society for Interferon and Cytokine Research (ISICR) and the International Cytokine Society (ICS)
    • Place of Presentation
      フィレンツェ、イタリア(ポスター)
    • Year and Date
      2011-10-11
  • [Presentation] マラリアにおける樹状細胞分化の異常と転写因子IRFファミリー2011

    • Author(s)
      市野素英,堀田千絵,田村智彦
    • Organizer
      第80回日本寄生虫学会
    • Place of Presentation
      東京(口頭発表)
    • Year and Date
      2011-07-18
  • [Remarks] 基盤研究(C)の成果発表プログラム(2012年8月4日実施):ひらめきすときめきサイエンス、平成24年度、プログラム名「のぞいてみよう!免疫のしくみ~大食い細胞マクロファージの働き~j研究代表者:市野素英

    • URL

      http://www.yokohamacu.ac.jp/hirameki/past/h24/index.html

  • [Remarks]

    • URL

      http://wwwuser.yokohamacu.ac.jp/~immunol/

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Published: 2015-07-16  

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