2013 Fiscal Year Final Research Report
Host immune responses and parasite delived substances associated with the establishment of chronic infection
| Project/Area Number |
23590497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
ISHIWATA Kenji 東京慈恵会医科大学, 医学部, 准教授 (00241307)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 消化管寄生虫 / 慢性感染 / 宿主免疫応答 / 寄生虫成分 / 樹状細胞 / 粘膜免疫 / 蠕虫 |
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| Research Abstract |
Although human body has an immune system which recognizes and rejects foreign pathogens, intestinal parasites establish in the gut for a long time; i.e. chronic infections. The mechanism of the infection was examined by mice model. Results suggested that the mouse immune response was suppressed at the very early phase of the infection. Parasite derived substances, such as excretory-secretory products, were thought to cause the suppression, however, the analysis is still in process.
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