2013 Fiscal Year Final Research Report
Searching the ligands of NLRP3 and NLRC4
| Project/Area Number |
23590513
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Nara Women's University |
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Principal Investigator |
OGURA Yasunori 奈良女子大学, 生活環境科学系, 教授 (60304557)
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| Project Period (FY) |
2011 – 2013
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| Keywords | NLRP3 / caspase-1 / IL-1beta |
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| Research Abstract |
In this proposal, I have aimed to identify the ligands of NLRP3 and NLRC4 proteins, which are regulators of the inflammatory caspase, caspase-1. Although I could not accomplish the final goal within the period, on the process of analysing the mechanism of the NLRP3 activation, I have gotten important progress to approach the signaling pathway that NLRP3 mediates; namely, (1) the NLRP3 activation coincides with the increase of intracellular ceramide; (2) chloride ions play an important role in the NLRP3 activation; (3) the extract from Zanthoxylum bungeanum inhibits the extracellular transport of the mature IL-1beta peptide.
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