2013 Fiscal Year Final Research Report
Integrated analysis of translocation of Pseudomonas aeruginosa from the colonized gastrointestinal tract
| Project/Area Number |
23590523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
GOTOH Naomasa 京都薬科大学, 薬学部, 教授 (30121560)
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| Co-Investigator(Kenkyū-buntansha) |
OKUDA Jun 香川県立保健医療大学, 保健医療学部, 教授 (90334276)
MINAGAWA Shu 京都薬科大学, 薬学部, 助教 (50445962)
HAYASHI Naoki 京都薬科大学, 薬学部, 助教 (70707463)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 緑膿菌 / バクテリアルトランスロケーション / ムチン層 / シデロフォア / mucD遺伝子 / 鞭毛 |
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| Research Abstract |
In this study, our findings provided at least three new mechanisms for translocation of Pseudomonas aeruginosa from the colonized gastrointestinal tract: (i) the pyoverdine synthesis gene (pvdE) facilitates penetration of P. aeruginosa through the epithelial cell barrier depending on regulating the expression of the exoS gene, impairs the defense function of tight junctions; (ii) P. aeruginosa can degrade interleukin-8 (IL-8) following the expression of the exoS and mucD gene; (iii) P. aeruginosa can penetrate the mucus layer using the flagellar motility and the mucin degradation. These results revealed that functions of P. aeruginosa can penetrate mucus layer and epithelial cells junction, which serve as important barriers in the intestinal epithelial tissue, and a survival strategy of P. aeruginosa to the host immune system.
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Research Products
(25 results)
