2013 Fiscal Year Final Research Report
Understandings of the HPV-induced tumorigenesis for developing anti-virus reagents.
| Project/Area Number |
23590540
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
SAKAI Hiroyuki 京都大学, ウイルス研究所, 准教授 (80281731)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | HPV / 腫瘍形成 / 抗ウイルス剤 / 子宮頸癌 |
|---|
| Research Abstract |
The infection of HPV is a major risk factor for cervical cancers and some of head and neck squamous cell carcinomas. For prevention of these cancers, it is critical to develop effective anti-virus reagents. In this project, I examined the mechanisms of virus replication and virus-induced tumorigenesis for identification of the candidate targets for anti-virus reagents.
It was revealed that E6 was important for the genome maintenance of HPV and that E7 was critical both for the virus-induced tumorigenesis and vegetative virus replication.
These results indicates that both E6 and E7 are good candidates for the developing anti-virus reagents. For the identification of the reagents, it is essential to clarify the action mechanisms of these oncoproteins.
|
