2013 Fiscal Year Final Research Report
Basic research on persistent infection of HCV and molecular mechanisms of RNA interference
| Project/Area Number |
23590555
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
KASAI MASATAKA 国立感染症研究所, 免疫部, 研究員 (10142134)
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| Co-Investigator(Kenkyū-buntansha) |
深澤 征義 国立感染症研究所, 細胞化学部 (20291130)
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| Project Period (FY) |
2011 – 2013
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| Keywords | HCV持続感染 / RNA干渉 / TRAX / Translin |
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| Research Abstract |
TRAX (Translin-associated factor X) is known as a component of RISC (RNA-induced silencing complex) that is involved in RNA interference (RNAi). Given the significant role of TRAX on RNAi machinery, we analyzed its effect on the mechanism of persistent infection of hepatitis C virus (HCV). Although we could not prove the involvement of TRAX in HCV infection during the study period, we obtained the following results for the nature of TRAX molecule: 1)TRAX protein alone cannot be cellularly expressed. 2)TRAX protein usually exists as a complex with Translin protein to escape from ubiquitin-independent proteasome degradation pathway 3) The C-terminal region of TRAX protein is susceptible to degradation.
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[Journal Article] Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus2014
Author(s)
Sugiyama K, Ebinuma H, Nakamoto N, Sakasegawa N, Murakami Y, Chu P-S, Usui S, Ishibashi Y, Wakayama Y, Taniki N, Murata H, Saito Y, Fukasawa M, Saito K, Yamagishi Y, Wakita T, Takaku H, Hibi T, Saito H, Kanai T
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Journal Title
PLOS ONE
Volume: 9(4)
Pages: e94460, 1-18
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[Journal Article] RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex2013
Author(s)
Ohtaka-Maruyama C, Hirai, S., Miwa, A., Heng, JI., Shitara, H., Ishii, R., Taya, C., Kawano, H., Kasai, M., Nakajima, K., and Okado, H.
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Journal Title
Cell Reports
Volume: 21
Pages: 458-471
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[Journal Article] Translin/TRAX deficiency affects mesenchymal differentiation programs and induces bone marrow failure2012
Author(s)
Ishida, R., Aoki, K., Nakahara, K., Fukuda, Y., Ohhori, M., Saito, Y., Kano, K., Matsuda, J., Asano, S., Maziarz, RT., and Kasai, M.
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Journal Title
Stem Cells and Human Diseases
Volume: Chapter 21
Pages: 468-476
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[Journal Article] RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex2012
Author(s)
Hirai, S., Miwa, A., Ohtaka-Maruyama C, Kasai, M., Okabe, S., Hata, Y., and Okado, H.
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Journal Title
EMBO J.
Volume: 31
Pages: 1190-1202
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