2013 Fiscal Year Final Research Report
Development of humanized mouse with functional immune systems
| Project/Area Number |
23590561
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Central Institute for Experimental Animals |
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Principal Investigator |
TAKAHASHI Takeshi 公益財団法人実験動物中央研究所, その他部局等, 室長 (80335215)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヒト化マウス |
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| Research Abstract |
Humanized mice, in which human hematopoietic and immune systems are reconstituted in severe immunodeficient NOG mice by transplanting human hematopoietic stem cells, have a lot of attention. In the humanized mouse, humoral immune responses against exogenous substances are generally weak. IgG responses, especially, have been difficult to induce. To improve the immune systems, we established a novel mouse strain which expresses human HLA class II genes. We found that the HLA-DR4 expressing NOG mice could produce antigen specific human IgG responses, when they were transplanted with HSC from HLA-haplotype identical donors. This model will be useful to study human immune responses and in developing various therapeutic drugs.
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[Journal Article] Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice2013
Author(s)
Ito R, Takahashi T, Katano I, Kawai K, Kamisako T, Ogura T, Ida-Tanaka M, Suemizu H, Nunomura S, Ra C, Mori A, Aiso S, Ito M
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Journal Title
Journal of Immunology
Volume: 191
Pages: 2890-2899
Peer Reviewed
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[Journal Article] Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice2012
Author(s)
Moriya K, Suzuki M, Watanabe Y, Takahashi T, Aoki Y, Uchiyama T, Kumaki S, Sasahara Y, Minegishi M, Kure S, Tsuchiya S, Sugamura K, Ishii N
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Journal Title
PLoS One
Volume: 7(6)
Pages: e37892
Peer Reviewed
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