2013 Fiscal Year Final Research Report
Regulation of diseases by chronic inflammation and obesity
| Project/Area Number |
23590567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Mie University |
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Principal Investigator |
OGATA Masato 三重大学, 医学(系)研究科(研究院), 教授 (60224094)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性炎症 / MAPキナーゼ / 血液細胞 / 代謝症候群 / p38 / 遺伝子改変マウス |
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| Research Abstract |
It is well established that obesity can exacerbate metabolic syndrome and glucose tolerance through induction of chronic inflammation. We have established p38alpha mutant mice in which p38alpha gene is disrupted in the hematopoietic cells. It is found that high fat diet-induced chronic inflammation in the adipose tissue and glucose tolerance is ameliorated in the mutant mice, suggesting that the p38alpha signaling cascade in the hematopoietic cells could be involved in the regulation of obesity-induced chronic inflammation and metabolic syndrome.
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Research Products
(12 results)
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[Journal Article] Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo2013
Author(s)
Kato, N., Matsumoto, M., Kogawa, M., Atkins, G.J., Findlay, D.M., Fujikawa, T., Oda, H., and Ogata, M.
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Journal Title
Journal of neuroinflammation
Volume: 10
Pages: 1
DOI
Peer Reviewed
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