2013 Fiscal Year Final Research Report
Roles of the GARP protein in functions of regulatory T cells
| Project/Area Number |
23590569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
FUJII Hodaka 大阪大学, 微生物病研究所, 准教授 (30302665)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 免疫寛容 / 自己免疫 / 制御性T細胞 / GARP蛋白 |
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| Research Abstract |
The awardee identified GARP as an activated regulatory T cell (T-reg)-specific cell surface protein. In this study, the role of GARP in the regulation of suppression of autoimmunity and its molecular mechanisms were analyzed by using transgenic mice overexpressing GARP in the T cell lineages and GARP-deficient mice. The analysis included (1) roles of GARP in the regulation of differentiation and functions of T-regs, (2) molecular mechanisms of regulation of T-reg functions by GARP, (3) roles of GARP in suppression of autoimmunity in vivo, and (4) mechanisms of expression regulation of GARP. The present study revealed that GARP plays critical roles in differentiation of T-regs and Th17 cells through TGFbeta signaling and expression regulation of GARP itself.
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