2013 Fiscal Year Final Research Report
Ophthalmologic assessment of retinal vessels as a biomarker of the pharmacological response to antiangiogenic cancer chemotherapy
| Project/Area Number |
23590638
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
ANDO YUICHI 名古屋大学, 医学部附属病院, 教授 (10360083)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUMA Ayako 名古屋大学, 大学院医学系研究科, 特任講師 (10467326)
ITO Yasuki 名古屋大学, 大学院医学系研究科, 准教授 (10313991)
TERASAKI Hiroko 名古屋大学, 大学院医学系研究科, 教授 (40207478)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 医薬品副作用 / 薬物相互作用 / がん薬物療法 / 眼底所見 |
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| Research Abstract |
To explore biomarkers of the pharmacological response to cancer chemotherapy including angiogenic inhibitors, this research assessed ophthalmologic findings of retinal vessels of total 137 patients who receiving cancer chemotherapy. The retinal vessel diameters; were more likely to shrink in those who responded to the preoperative treatment of colorectal cancer; clearly reflected therapeutic efficacy in those with refractory multiple myeloma; and showed a marked reduction in those who obtained long-term stable disease during the treatment of metastatic colorectal cancer.
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